Tafluprost

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Tafluprost

Systematic (IUPAC) name
isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate
Clinical data
Trade names	Saflutan, Taflotan, Tapros, Zioptan
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	C (US)
Legal status	℞-only (US)
Routes	Topical (eye drops)
Identifiers
CAS number	209860-87-7
ATC code	S01EE05
PubChem	CID 6433101
ChemSpider	8044182
UNII	1O6WQ6T7G3^Y
ChEBI	CHEBI:66899^Y
ChEMBL	CHEMBL1963683
Chemical data
Formula	C₂₅H₃₄F₂O₅
Mol. mass	452.531266 g/mol
SMILES CC(C)OC(=O)CCC\C=C/CC(C(O)CC1O)C1\C=C\C(F)(F)COc2ccccc2

Tafluprost (trade names Taflotan, marketed by Santen Pharmaceutical Co. and Zioptan, by Merck (U.S.)) is a prostaglandin analogue used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes.^[1]^[2]

Taflotan contains 15 µg/ml Tafluprost. Taflotan sine is a preservative-free, single-dose formulation containing 0.3 ml per dose.^[3]

References

Ophthalmologicals: antiglaucoma preparations and miotics (S01E)

muscarinic	Aceclidine Pilocarpine

muscarinic/nicotinic	Acetylcholine Carbachol

Acetylcholinesterase inhibitors	Demecarium Ecothiopate Stigmine (Fluostigmine Neostigmine Physostigmine) Paraoxon

Other agents

anat (g/a/p)/phys/devp/prot

noco/cong/tumr, epon

proc, drug (S1A/1E/1F/1L)

Precursor

Precursor

Active

D/J	D₂

E/F	E₂ (Dinoprostone): Enprostil Sulprostone E₁ (Alprostadil): Misoprostol Gemeprost F_2α (Dinoprost): Bimatoprost Carboprost Latanoprost Tafluprost Travoprost Unoprostone

I	I₂ (Prostacyclin/Epoprostenol): Beraprost Iloprost Treprostinil

Precursor	Arachidonic acid 5-hydroperoxide

Initial	A₄ B₄

SRS-A	C₄ D₄ E₄

By function

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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