TUBG1
From Wikipedia, the free encyclopedia
| Tubulin, gamma 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TUBG1; GCP-1; TUBG; TUBGCP1 | ||||||||||||
| External IDs | OMIM: 191135 HomoloGene: 833 GeneCards: TUBG1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7283 | 103733 | |||||||||||
| Ensembl | ENSG00000131462 | ENSMUSG00000035198 | |||||||||||
| UniProt | P23258 | P83887 | |||||||||||
| RefSeq (mRNA) | NM_001070 | NM_134024 | |||||||||||
| RefSeq (protein) | NP_001061 | NP_598785 | |||||||||||
| Location (UCSC) | Chr 17: 40.76 – 40.77 Mb | Chr 11: 101.12 – 101.13 Mb | |||||||||||
| PubMed search | |||||||||||||
Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene. [1] This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle.
References
- ↑ "Entrez Gene: Tubulin, gamma 1". Retrieved 2012-06-06T02:23:37.703498-08:00.
Further reading
- Zhang, X.; Chen, Q.; Feng, J.; Hou, J.; Yang, F.; Liu, J.; Jiang, Q.; Zhang, C. (2009). "Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the TuRC to the centrosome". Journal of Cell Science 122 (13): 2240–2251. doi:10.1242/jcs.042747. PMID 19509060.
- Lau, A. S.; Mruk, D. D. (2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology 144 (4): 1549–1563. doi:10.1210/en.2002-220893. PMID 12639940.
- Feng, Y.; Olson, E. C.; Stukenberg, P. T.; Flanagan, L. A.; Kirschner, M. W.; Walsh, C. A. (2000). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron 28 (3): 665–679. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258.
- Hsu, L. C.; White, R. L. (1998). "BRCA1 is associated with the centrosome during mitosis". Proceedings of the National Academy of Sciences of the United States of America 95 (22): 12983–12988. PMC 23679. PMID 9789027.
- Manning, J. A.; Shalini, S.; Risk, J. M.; Day, C. L.; Kumar, S. (2010). "A Direct Interaction with NEDD1 Regulates γ-Tubulin Recruitment to the Centrosome". In Hotchin, Neil A. PLoS ONE 5 (3): e9618. doi:10.1371/journal.pone.0009618. PMC 2835750. PMID 20224777.
- Aldaz, H.; Rice, L. M.; Stearns, T.; Agard, D. A. (2005). "Insights into microtubule nucleation from the crystal structure of human γ-tubulin". Nature 435 (7041): 523–527. doi:10.1038/nature03586. PMID 15917813.
- Niu, Y.; Liu, T.; Tse, G. M. K.; Sun, B.; Niu, R.; Li, H. M.; Wang, H.; Yang, Y.; Ye, X.; Wang, Y.; Yu, Q.; Zhang, F. (2009). "Increased expression of centrosomal α, γ-tubulin in atypical ductal hyperplasia and carcinoma of the breast". Cancer Science 100 (4): 580–587. doi:10.1111/j.1349-7006.2008.01075.x. PMID 19215229.
- Hampe, C.; Ardila-Osorio, H.; Fournier, M.; Brice, A.; Corti, O. (2006). "Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity". Human Molecular Genetics 15 (13): 2059–2075. doi:10.1093/hmg/ddl131. PMID 16714300.
- Zyss, D.; Montcourrier, P.; Vidal, B.; Anguille, C.; Mérezègue, F.; Sahuquet, A.; Mangeat, P. H.; Coopman, P. J. (2005). "The Syk Tyrosine Kinase Localizes to the Centrosomes and Negatively Affects Mitotic Progression". Cancer Research 65 (23): 10872–10880. doi:10.1158/0008-5472.CAN-05-1270. PMID 16322234.
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