TRPM5

From Wikipedia, the free encyclopedia
Transient receptor potential cation channel, subfamily M, member 5
Identifiers
SymbolsTRPM5; LTRPC5; MTR1
External IDsOMIM: 604600 MGI: 1861718 HomoloGene: 22818 IUPHAR: TRPM5 ChEMBL: 1628468 GeneCards: TRPM5 Gene
Orthologs
SpeciesHumanMouse
Entrez2985056843
EnsemblENSG00000070985ENSMUSG00000009246
UniProtQ9NZQ8Q9JJH7
RefSeq (mRNA)NM_014555NM_020277
RefSeq (protein)NP_055370NP_064673
Location (UCSC)Chr 11:
2.43 – 2.44 Mb		Chr 7:
143.07 – 143.09 Mb
PubMed search
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Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.[1][2]

Function

TRPM5 is a key component of taste transduction in the gustatory system of bitter, sweet and umami tastes being activated by high levels of intracellular calcium. The calcium dependent opening of TRPM5 produces a depolarising generator potential which leads to an action potential.[3]

See also

References

  1. ↑ Prawitt D, Enklaar T, Klemm G, Gärtner B, Spangenberg C, Winterpacht A, Higgins M, Pelletier J, Zabel B (January 2000). "Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression". Hum. Mol. Genet. 9 (2): 203–16. doi:10.1093/hmg/9.2.203. PMID 10607831. 
  2. ↑ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  3. ↑ Chaudhari N, Roper SD (August 2010). "The cell biology of taste". J. Cell Biol. 190 (3): 285–96. doi:10.1083/jcb.201003144. PMC 2922655. PMID 20696704. 

Further reading

  • Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6. 
  • Liman ER (2007). "TRPM5 and taste transduction". Handb Exp Pharmacol. Handbook of Experimental Pharmacology 179 (179): 287–98. doi:10.1007/978-3-540-34891-7_17. ISBN 978-3-540-34889-4. PMID 17217064. 
  • Holzer P (July 2011). "Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system". Pharmacology and Therapeutics 131 (1): 142–170. doi:10.1016/j.pharmthera.2011.03.006. PMID 21420431. 
  • Boesmans W, Owsianik G, Tack J, Voets T, Vanden Berghe P. (January 2011). "TRP channels in neurogastroenterology: opportunities for therapeutic intervention". British Journal of Pharmacology 162 (1): 18–37. doi:10.1111/j.1476-5381.2010.01009.x. PMID 20804496. 
  • Emily R Liman (2010). "Changing Taste by Targeting the Ion Channel TRPM5". The Open Drug Discovery Journal 2: 98–102. 
  • Brixel LR, Monteilh-Zoller MK, Ingenbrandt CS, Fleig A, Penner R, Enklaar T, Zabel BU, Prawitt D. (June 2010). "TRPM5 regulates glucose-stimulated insulin secretion". Pflugers Archive - European Journal of Physiology 460 (1): 69–76. doi:10.1007/s00424-010-0835-z. PMID 20393858. 
  • Oliveira-Maia AJ, Stapleton-Kotloski JR, Lyall V, Phan TH, Mummalaneni S, Melone P, Desimone JA, Nicolelis MA, Simon SA (February 2009). "Nicotine activates TRPM5-dependent and independent taste pathways". Proceedings of the National Academy of Sciences of the United States of America 106 (5): 1596–1601. doi:10.1073/pnas.0810184106. PMID 19164511. 
  • Dan Liu, Zheng Zhang and Emily R. Liman (May 2005). "Extracellular Acid Block and Acid-enhanced Inactivation of the Ca2+-activated Cation Channel TRPM5 Involve Residues in the S3-S4 and S5-S6 Extracellular Domains". The Journal of Biological Chemistry 280 (21): 20691–20699. doi:10.1074/jbc.M414072200. PMID 15731110. 
  • Liu D, Liman ER (December 2003). "Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5". Proceedings of the National Academy of Sciences of the United States of America 100 (25): 15160–15165. doi:10.1073 pnas.2334159100. PMID 14657398. 
  • Wu LJ, Sweet TB, Clapham DE (September 2010). "International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family". Pharmacological Reviews 62 (3): 381–404. doi:10.1124/pr.110.002725. PMID 20716668. 

External links

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