TRPM4
From Wikipedia, the free encyclopedia
| Transient receptor potential cation channel, subfamily M, member 4 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TRPM4; PFHB1B; TRPM4B | ||||||||||||
| External IDs | OMIM: 606936 MGI: 1915917 HomoloGene: 23033 IUPHAR: TRPM4 ChEMBL: 1628469 GeneCards: TRPM4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 54795 | 68667 | |||||||||||
| Ensembl | ENSG00000130529 | ENSMUSG00000038260 | |||||||||||
| UniProt | Q8TD43 | Q7TN37 | |||||||||||
| RefSeq (mRNA) | NM_001195227 | NM_175130 | |||||||||||
| RefSeq (protein) | NP_001182156 | NP_780339 | |||||||||||
| Location (UCSC) | Chr 19: 49.66 – 49.72 Mb | Chr 7: 45.3 – 45.33 Mb | |||||||||||
| PubMed search | |||||||||||||
Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.[1][2]
See also
References
- ↑ Xu XZ, Moebius F, Gill DL, Montell C (September 2001). "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform". Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10692–7. doi:10.1073/pnas.191360198. PMC 58528. PMID 11535825.
- ↑ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
Further reading
- Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
- Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP (2002). "TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization". Cell 109 (3): 397–407. doi:10.1016/S0092-8674(02)00719-5. PMID 12015988.
- Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP (2004). "TRPM4 regulates calcium oscillations after T cell activation". Science 306 (5700): 1374–1377. doi:10.1126/science.1098845. PMID 15550671.
- Vennekens R, Nilius B (2007). "Insights into TRPM4 function, regulation and physiological role". Handb Exp Pharmacol. Handbook of Experimental Pharmacology 179 (179): 269–85. doi:10.1007/978-3-540-34891-7_16. ISBN 978-3-540-34889-4. PMID 17217063.
- Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M (2007). "Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4". Nat Immunol 8 (3): 312–320. doi:10.1038/ni1441. PMID 17293867.
- Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P (2008). "The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells". Nat Immunol 9 (10): 1148–56. doi:10.1038/ni.1648. PMC 2956271. PMID 18758465.
External links
- TRPM4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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