TRIM37

From Wikipedia, the free encyclopedia
Tripartite motif containing 37
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsTRIM37; MUL; POB1; TEF3
External IDsOMIM: 605073 MGI: 2153072 HomoloGene: 9084 GeneCards: TRIM37 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez459168729
EnsemblENSG00000108395ENSMUSG00000018548
UniProtO94972Q6PCX9
RefSeq (mRNA)NM_001005207NM_197987
RefSeq (protein)NP_001005207NP_932104
Location (UCSC)Chr 17:
57.06 – 57.18 Mb
Chr 11:
87.13 – 87.22 Mb
PubMed search

Tripartite motif-containing protein 37 is a protein that in humans is encoded by the TRIM37 gene.[2][3][4]

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein–protein and/or protein–nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.[4]

Interactions

TRIM37 has been shown to interact with PRC1.[5]

See also

References

  1. Finn (2006, p. 170)
  2. Avela K, Lipsanen-Nyman M, Perheentupa J, Wallgren-Pettersson C, Marchand S, Faure S, Sistonen P, de la Chapelle A, Lehesjoki AE (May 1997). "Assignment of the mulibrey nanism gene to 17q by linkage and linkage-disequilibrium analysis". Am J Hum Genet 60 (4): 896–902. PMC 1712467. PMID 9106536. 
  3. Avela K, Lipsanen-Nyman M, Idanheimo N, Seemanova E, Rosengren S, Makela TP, Perheentupa J, Chapelle AD, Lehesjoki AE (Aug 2000). "Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism". Nat Genet 25 (3): 298–301. doi:10.1038/77053. PMID 10888877. 
  4. 4.0 4.1 "Entrez Gene: TRIM37 tripartite motif-containing 37". 
  5. Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading


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