TRIM37
Tripartite motif containing 37 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | TRIM37; MUL; POB1; TEF3 | ||||||||||||
External IDs | OMIM: 605073 MGI: 2153072 HomoloGene: 9084 GeneCards: TRIM37 Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 4591 | 68729 | |||||||||||
Ensembl | ENSG00000108395 | ENSMUSG00000018548 | |||||||||||
UniProt | O94972 | Q6PCX9 | |||||||||||
RefSeq (mRNA) | NM_001005207 | NM_197987 | |||||||||||
RefSeq (protein) | NP_001005207 | NP_932104 | |||||||||||
Location (UCSC) | Chr 17: 57.06 – 57.18 Mb | Chr 11: 87.13 – 87.22 Mb | |||||||||||
PubMed search | |||||||||||||
Tripartite motif-containing protein 37 is a protein that in humans is encoded by the TRIM37 gene.[2][3][4]
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein–protein and/or protein–nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.[4]
Interactions
TRIM37 has been shown to interact with PRC1.[5]
See also
References
- ↑ Finn (2006, p. 170)
- ↑ Avela K, Lipsanen-Nyman M, Perheentupa J, Wallgren-Pettersson C, Marchand S, Faure S, Sistonen P, de la Chapelle A, Lehesjoki AE (May 1997). "Assignment of the mulibrey nanism gene to 17q by linkage and linkage-disequilibrium analysis". Am J Hum Genet 60 (4): 896–902. PMC 1712467. PMID 9106536.
- ↑ Avela K, Lipsanen-Nyman M, Idanheimo N, Seemanova E, Rosengren S, Makela TP, Perheentupa J, Chapelle AD, Lehesjoki AE (Aug 2000). "Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism". Nat Genet 25 (3): 298–301. doi:10.1038/77053. PMID 10888877.
- ↑ 4.0 4.1 "Entrez Gene: TRIM37 tripartite motif-containing 37".
- ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Further reading
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
- Zapata JM, Pawlowski K, Haas E, et al. (2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". J. Biol. Chem. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055.
- Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
- Lehesjoki AE, Reed VA, Mark Gardiner R, Greene ND (2002). "Expression of MUL, a gene encoding a novel RBCC family ring-finger protein, in human and mouse embryogenesis". Mech. Dev. 108 (1–2): 221–5. doi:10.1016/S0925-4773(01)00491-9. PMID 11578880.
- Kallijärvi J, Avela K, Lipsanen-Nyman M, et al. (2002). "The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder". Am. J. Hum. Genet. 70 (5): 1215–28. doi:10.1086/340256. PMC 447596. PMID 11938494.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Jagiello P, Hammans C, Wieczorek S, et al. (2003). "A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity". Hum. Mutat. 21 (6): 630–5. doi:10.1002/humu.10220. PMID 12754710.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Hämäläinen RH, Avela K, Lambert JA, et al. (2004). "Novel mutations in the TRIM37 gene in Mulibrey Nanism". Hum. Mutat. 23 (5): 522. doi:10.1002/humu.9233. PMID 15108285.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kallijärvi J, Lahtinen U, Hämäläinen R, et al. (2005). "TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase". Exp. Cell Res. 308 (1): 146–55. doi:10.1016/j.yexcr.2005.04.001. PMID 15885686.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Karlberg N, Jalanko H, Kallijärvi J, et al. (2006). "Insulin resistance syndrome in subjects with mutated RING finger protein TRIM37". Diabetes 54 (12): 3577–81. doi:10.2337/diabetes.54.12.3577. PMID 16306379.
- Hämäläinen RH, Joensuu T, Kallijärvi J, Lehesjoki AE (2006). "Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing". Gene 366 (1): 180–8. doi:10.1016/j.gene.2005.08.008. PMID 16310976.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein–protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Hämäläinen RH, Mowat D, Gabbett MT, et al. (2007). "Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism". Clin. Genet. 70 (6): 473–9. doi:10.1111/j.1399-0004.2006.00700.x. PMID 17100991.
- Doğanc T, Yüksel Konuk BE, Alpan N, et al. (2007). "A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy". Clin. Dysmorphol. 16 (3): 173–6. doi:10.1097/MCD.0b013e3280f6d00b. PMID 17551331.