TRIM25

From Wikipedia, the free encyclopedia

Tripartite motif containing 25

Identifiers

Symbols

TRIM25; EFP; RNF147; Z147; ZNF147

External IDs

OMIM: 600453 MGI: 102749 HomoloGene: 48325 GeneCards: TRIM25 Gene

EC number

6.3.2.19, 6.3.2.n3

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • ubiquitin-protein ligase activity • protein binding • zinc ion binding
Cellular component	• nucleus • nucleolus • cytoplasm • cytosol • cell junction
Biological process	• regulation of transcription, DNA-dependent • virus-host interaction • negative regulation of type I interferon production • innate immune response • defense response to virus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
54.97 – 54.99 Mb

Chr 11:
89 – 89.02 Mb

PubMed search

Tripartite motif-containing protein 25 is a protein that in humans is encoded by the TRIM25 gene.^[1]^[2]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.^[2]

References

↑ Inoue S, Orimo A, Matsuda Y, Inazawa J, Emi M, Nakamura Y, Hori T, Muramatsu M (Jul 1995). "Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family". Genomics 25 (2): 581–3. doi:10.1016/0888-7543(95)80064-S. PMID 7789997.
↑ 2.0 2.1 "Entrez Gene: TRIM25 tripartite motif-containing 25".

Horie K, Urano T, Ikeda K, Inoue S (2003). "Estrogen-responsive RING finger protein controls breast cancer growth". J. Steroid Biochem. Mol. Biol. 85 (2–5): 101–4. doi:10.1016/S0960-0760(03)00209-7. PMID 12943693.
Inoue S, Orimo A, Hosoi T et al. (1994). "Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11117–21. doi:10.1073/pnas.90.23.11117. PMC 47933. PMID 8248217.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Ikeda K, Inoue S, Orimo A et al. (1997). "Multiple regulatory elements and binding proteins of the 5'-flanking region of the human estrogen-responsive finger protein (efp) gene". Biochem. Biophys. Res. Commun. 236 (3): 765–71. doi:10.1006/bbrc.1997.7046. PMID 9245730.
Ikeda K, Orimo A, Higashi Y et al. (2000). "Efp as a primary estrogen-responsive gene in human breast cancer". FEBS Lett. 472 (1): 9–13. doi:10.1016/S0014-5793(00)01421-6. PMID 10781795.
Reymond A, Meroni G, Fantozzi A et al. (2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
Urano T, Saito T, Tsukui T et al. (2002). "Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth". Nature 417 (6891): 871–5. doi:10.1038/nature00826. PMID 12075357.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shimada N, Suzuki T, Inoue S et al. (2004). "Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues". Mol. Cell. Endocrinol. 218 (1–2): 147–53. doi:10.1016/j.mce.2003.12.008. PMID 15130519.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Suzuki T, Urano T, Tsukui T et al. (2005). "Estrogen-responsive finger protein as a new potential biomarker for breast cancer". Clin. Cancer Res. 11 (17): 6148–54. doi:10.1158/1078-0432.CCR-05-0040. PMID 16144914.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Nakayama H, Sano T, Motegi A et al. (2005). "Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma". Pathol. Int. 55 (11): 707–15. doi:10.1111/j.1440-1827.2005.01900.x. PMID 16271083.
Nakasato N, Ikeda K, Urano T et al. (2007). "A ubiquitin E3 ligase Efp is up-regulated by interferons and conjugated with ISG15". Biochem. Biophys. Res. Commun. 351 (2): 540–6. doi:10.1016/j.bbrc.2006.10.061. PMID 17069755.
Nakajima A, Maruyama S, Bohgaki M et al. (2007). "Ligand-dependent transcription of estrogen receptor alpha is mediated by the ubiquitin ligase EFP". Biochem. Biophys. Res. Commun. 357 (1): 245–51. doi:10.1016/j.bbrc.2007.03.134. PMID 17418098.

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TRIM25

References

Further reading