TPCN2
From Wikipedia, the free encyclopedia
| Two pore segment channel 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TPCN2; SHEP10; TPC2 | ||||||||||||
| External IDs | OMIM: 612163 MGI: 2385297 HomoloGene: 16375 IUPHAR: TPC2 GeneCards: TPCN2 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 219931 | 233979 | |||||||||||
| Ensembl | ENSG00000162341 | ENSMUSG00000048677 | |||||||||||
| UniProt | Q8NHX9 | Q8BWC0 | |||||||||||
| RefSeq (mRNA) | NM_139075 | NM_146206 | |||||||||||
| RefSeq (protein) | NP_620714 | NP_666318 | |||||||||||
| Location (UCSC) | Chr 11: 68.82 – 68.86 Mb | Chr 7: 145.25 – 145.28 Mb | |||||||||||
| PubMed search | |||||||||||||
Two pore segment channel 2 (TPC2) is a human protein encoded by the TPCN2 is a protein which in humans is encoded by the TPCN2 gene.[1] TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).[2]
See also
References
- ↑ "Entrez Gene: two pore segment channel 2".
- ↑ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
Further reading
- Sulem P, Gudbjartsson DF, Stacey SN, et al. (2008). "Two newly identified genetic determinants of pigmentation in Europeans.". Nat. Genet. 40 (7): 835–7. doi:10.1038/ng.160. PMID 18488028.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels.". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Calcraft PJ, Ruas M, Pan Z, et al. (2009). "NAADP mobilizes calcium from acidic organelles through two-pore channels.". Nature 459 (7246): 596–600. doi:10.1038/nature08030. PMC 2761823. PMID 19387438.
- Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification.". Nature 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
- Fu GK, Wang JT, Yang J, et al. (2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
External links
- TPCN2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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