TOPBP1
From Wikipedia, the free encyclopedia
| Topoisomerase (DNA) II binding protein 1 | |||||||||||||
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 Rendering of TOPBP1 from PDB 1WF6 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TOPBP1; TOP2BP1 | ||||||||||||
| External IDs | OMIM: 607760 MGI: 1920018 HomoloGene: 38262 ChEMBL: 3175 GeneCards: TOPBP1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11073 | 235559 | |||||||||||
| Ensembl | ENSG00000163781 | ENSMUSG00000032555 | |||||||||||
| UniProt | Q92547 | Q6ZQF0 | |||||||||||
| RefSeq (mRNA) | NM_007027 | NM_176979 | |||||||||||
| RefSeq (protein) | NP_008958 | NP_795953 | |||||||||||
| Location (UCSC) | Chr 3: 133.32 – 133.38 Mb | Chr 9: 103.31 – 103.35 Mb | |||||||||||
| PubMed search | |||||||||||||
DNA topoisomerase 2-binding protein 1 is an enzyme that in humans is encoded by the TOPBP1 gene.[1][2][3]
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.[3]
Interactions
TOPBP1 has been shown to interact with RAD9A,[4] E2F1,[5][6] Promyelocytic leukemia protein,[7] ZBTB17[8] and UBR5.[9]
Clinical relevance
This gene may be involved in the development of ovarian and breast cancer.[10]
References
- ↑ Yamane K, Kawabata M, Tsuruo T (February 1998). "A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator". Eur J Biochem 250 (3): 794–9. doi:10.1111/j.1432-1033.1997.00794.x. PMID 9461304.
- ↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
- ↑ 3.0 3.1 "Entrez Gene: TOPBP1 topoisomerase (DNA) II binding protein 1".
- ↑ Mäkiniemi, M; Hillukkala T, Tuusa J, Reini K, Vaara M, Huang D, Pospiech H, Majuri I, Westerling T, Mäkelä T P, Syväoja J E (August 2001). "BRCT domain-containing protein TopBP1 functions in DNA replication and damage response". J. Biol. Chem. (United States) 276 (32): 30399–406. doi:10.1074/jbc.M102245200. ISSN 0021-9258. PMID 11395493.
- ↑ Liu, Kang; Lin Fang-Tsyr, Ruppert J Michael, Lin Weei-Chin (May 2003). "Regulation of E2F1 by BRCT domain-containing protein TopBP1". Mol. Cell. Biol. (United States) 23 (9): 3287–304. doi:10.1128/MCB.23.9.3287-3304.2003. ISSN 0270-7306. PMC 153207. PMID 12697828.
- ↑ Yu, Xiaochun; Chini Claudia Christiano Silva, He Miao, Mer Georges, Chen Junjie (October 2003). "The BRCT domain is a phospho-protein binding domain". Science (United States) 302 (5645): 639–42. doi:10.1126/science.1088753. PMID 14576433.
- ↑ Xu, Zhi-Xiang; Timanova-Atanasova Anna, Zhao Rui-Xun, Chang Kun-Sang (June 2003). "PML colocalizes with and stabilizes the DNA damage response protein TopBP1". Mol. Cell. Biol. (United States) 23 (12): 4247–56. doi:10.1128/MCB.23.12.4247-4256.2003. ISSN 0270-7306. PMC 156140. PMID 12773567.
- ↑ Herold, Steffi; Wanzel Michael, Beuger Vincent, Frohme Carsten, Beul Dorothee, Hillukkala Tomi, Syvaoja Juhani, Saluz Hans-Peter, Haenel Frank, Eilers Martin (September 2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1". Mol. Cell (United States) 10 (3): 509–21. doi:10.1016/S1097-2765(02)00633-0. ISSN 1097-2765. PMID 12408820.
- ↑ Honda, Yoshiomi; Tojo Masahide, Matsuzaki Kazuhito, Anan Tadashi, Matsumoto Mitsuhiro, Ando Masayuki, Saya Hideyuki, Nakao Mitsuyoshi (February 2002). "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response". J. Biol. Chem. (United States) 277 (5): 3599–605. doi:10.1074/jbc.M104347200. ISSN 0021-9258. PMID 11714696.
- ↑ Forma E, Wójcik-Krowiranda K, Bieńkiewicz A, Bryś M (2013) Molecular basis of gynecological oncology - TopBP1 protein as the guardian of genome integrity. Ginekol Pol 84(5):373-376
Further reading
- Yamane K, Tsuruo T (1999). "Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA.". Oncogene 18 (37): 5194–203. doi:10.1038/sj.onc.1202922. PMID 10498869.
- Mäkiniemi M, Hillukkala T, Tuusa J, et al. (2001). "BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.". J. Biol. Chem. 276 (32): 30399–406. doi:10.1074/jbc.M102245200. PMID 11395493.
- Honda Y, Tojo M, Matsuzaki K, et al. (2002). "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.". J. Biol. Chem. 277 (5): 3599–605. doi:10.1074/jbc.M104347200. PMID 11714696.
- Yamane K, Wu X, Chen J (2002). "A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.". Mol. Cell. Biol. 22 (2): 555–66. doi:10.1128/MCB.22.2.555-566.2002. PMC 139754. PMID 11756551.
- Boner W, Taylor ER, Tsirimonaki E, et al. (2002). "A Functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1.". J. Biol. Chem. 277 (25): 22297–303. doi:10.1074/jbc.M202163200. PMID 11934899.
- Herold S, Wanzel M, Beuger V, et al. (2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1.". Mol. Cell 10 (3): 509–21. doi:10.1016/S1097-2765(02)00633-0. PMID 12408820.
- Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Liu K, Lin FT, Ruppert JM, Lin WC (2003). "Regulation of E2F1 by BRCT domain-containing protein TopBP1.". Mol. Cell. Biol. 23 (9): 3287–304. doi:10.1128/MCB.23.9.3287-3304.2003. PMC 153207. PMID 12697828.
- Xu ZX, Timanova-Atanasova A, Zhao RX, Chang KS (2003). "PML colocalizes with and stabilizes the DNA damage response protein TopBP1.". Mol. Cell. Biol. 23 (12): 4247–56. doi:10.1128/MCB.23.12.4247-4256.2003. PMC 156140. PMID 12773567.
- Yamane K, Chen J, Kinsella TJ (2003). "Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.". Cancer Res. 63 (12): 3049–53. PMID 12810625.
- Greer DA, Besley BD, Kennedy KB, Davey S (2003). "hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation.". Cancer Res. 63 (16): 4829–35. PMID 12941802.
- Manke IA, Lowery DM, Nguyen A, Yaffe MB (2003). "BRCT repeats as phosphopeptide-binding modules involved in protein targeting.". Science 302 (5645): 636–9. doi:10.1126/science.1088877. PMID 14576432.
- Yu X, Chini CC, He M, et al. (2003). "The BRCT domain is a phospho-protein binding domain.". Science 302 (5645): 639–42. doi:10.1126/science.1088753. PMID 14576433.
- Liu K, Luo Y, Lin FT, Lin WC (2004). "TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.". Genes Dev. 18 (6): 673–86. doi:10.1101/gad.1180204. PMC 387242. PMID 15075294.
- Reini K, Uitto L, Perera D, et al. (2005). "TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis.". Chromosoma 112 (7): 323–30. doi:10.1007/s00412-004-0277-5. PMID 15138768.
- Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.
- Yoshida K, Inoue I (2004). "Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor.". Oncogene 23 (37): 6250–60. doi:10.1038/sj.onc.1207829. PMID 15195143.
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