TNRC6B

From Wikipedia, the free encyclopedia
Trinucleotide repeat containing 6B
Identifiers
SymbolsTNRC6B; KIAA1093
External IDsOMIM: 610740 MGI: 2443730 HomoloGene: 66194 GeneCards: TNRC6B Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez23112213988
EnsemblENSG00000100354ENSMUSG00000047888
UniProtQ9UPQ9Q8BKI2
RefSeq (mRNA)NM_001024843NM_144812
RefSeq (protein)NP_001020014NP_659061
Location (UCSC)Chr 22:
40.44 – 40.73 Mb
Chr 15:
80.71 – 80.94 Mb
PubMed search

Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene.[1]

Interactions

TNRC6B has been shown to interact with EIF2C2.[2] It is also known to associate with argonaute proteins and has been shown to be required for miRNA-guided gene silencing in HeLa cells.[3]

References

  1. "Entrez Gene: TNRC6B trinucleotide repeat containing 6B". 
  2. Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID 17891150. 
  3. Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Lührmann R, Tuschl T (December 2005). "Identification of novel argonaute-associated proteins". Curr. Biol. 15 (23): 2149–55. doi:10.1016/j.cub.2005.10.048. PMID 16289642. 

Further reading

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