TLR 7

Toll-like receptor 7
Identifiers
Symbols	TLR7; TLR7-like
External IDs	OMIM: 300365 MGI: 2176882 HomoloGene: 75060 ChEMBL: 5936 GeneCards: TLR7 Gene
Gene Ontology Molecular function • double-stranded RNA binding • single-stranded RNA binding • transmembrane signaling receptor activity • drug binding • siRNA binding Cellular component • Golgi membrane • cytoplasm • lysosome • endosome • endoplasmic reticulum • endoplasmic reticulum membrane • plasma membrane • endosome membrane • integral to membrane • early phagosome • endolysosome membrane Biological process • toll-like receptor signaling pathway • microglial cell activation involved in immune response • MyD88-dependent toll-like receptor signaling pathway • inflammatory response • I-kappaB phosphorylation • positive regulation of chemokine production • positive regulation of interleukin-6 production • positive regulation of interleukin-8 production • toll-like receptor 7 signaling pathway • toll-like receptor 9 signaling pathway • response to chemical stimulus • positive regulation of NF-kappaB import into nucleus • positive regulation of interferon-gamma biosynthetic process • innate immune response • positive regulation of interferon-alpha biosynthetic process • positive regulation of interferon-beta biosynthetic process • positive regulation of interleukin-8 biosynthetic process • positive regulation of inflammatory response • defense response to virus • pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response • cellular response to mechanical stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51284	170743
Ensembl	ENSG00000196664	ENSMUSG00000044583
UniProt	Q9NYK1	P58681
RefSeq (mRNA)	NM_016562	NM_133211
RefSeq (protein)	NP_057646	NP_573474
Location (UCSC)	Chr X: 12.89 – 12.91 Mb	Chr X: 167.3 – 167.33 Mb
PubMed search
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Toll-like receptor 7, also known as TLR7, is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds.^[1]

Function

TLR7 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X.^[2]

TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.

Clinical significance

Imiquimod acts upon TLR7.^[3]

References

Further reading

External links

• Toll-Like Receptor 7 at the US National Library of Medicine Medical Subject Headings (MeSH)