TLR6

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Toll-like receptor 6

Identifiers

TLR6; CD286

External IDs

OMIM: 605403 MGI: 1341296 HomoloGene: 21223 GeneCards: TLR6 Gene

Gene Ontology
Molecular function	• receptor activity • transmembrane signaling receptor activity • diacyl lipopeptide binding • protein heterodimerization activity • lipopeptide binding
Cellular component	• plasma membrane • integral to plasma membrane • phagocytic vesicle membrane • Toll-like receptor 2-Toll-like receptor 6 protein complex
Biological process	• toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • inflammatory response • immune response • signal transduction • activation of NF-kappaB-inducing kinase activity • toll-like receptor 2 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 6 signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • T-helper 1 type immune response • detection of diacyl bacterial lipopeptide • defense response to bacterium • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of JUN kinase activity • innate immune response • positive regulation of interleukin-6 biosynthetic process • regulation of cytokine secretion • cellular response to diacyl bacterial lipopeptide
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
38.83 – 38.86 Mb

Chr 5:
64.95 – 64.96 Mb

PubMed search

Toll-like receptor 6 is a protein that in humans is encoded by the TLR6 gene.^[1] TLR6 has also been designated as CD286 (cluster of differentiation 286).

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns (MAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.^[2]

References

↑ Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S (Jun 1999). "TLR6: A novel member of an expanding toll-like receptor family". Gene 231 (1–2): 59–65. doi:10.1016/S0378-1119(99)00098-0. PMID 10231569.
↑ "Entrez Gene: TLR6 toll-like receptor 6".

External links

Toll-Like Receptor 6 at the US National Library of Medicine Medical Subject Headings (MeSH)
TLR6 human gene location in the UCSC Genome Browser.
TLR6 human gene details in the UCSC Genome Browser.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Signaling pathway: TLR signaling pathway

Receptor

TLR 4

TLR 1 TLR 2 TLR 6

TLR 5 TLR 10

Other external

CD14
MD2
LBP

Internal

adaptor: MYD88 TRIF TIRAP TRAF6 TOLLIP

IRAK1 IRAK4

IRF3

TLR 3 TLR 7 TLR 8 TLR 9

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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TLR6

References

Further reading

External links