TLN2
From Wikipedia, the free encyclopedia
| Talin 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | TLN2; ILWEQ | ||||||||||||
| External IDs | OMIM: 607349 HomoloGene: 56692 GeneCards: TLN2 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 83660 | 70549 | |||||||||||
| Ensembl | ENSG00000171914 | ENSMUSG00000052698 | |||||||||||
| UniProt | Q9Y4G6 | Q71LX4 | |||||||||||
| RefSeq (mRNA) | NM_015059 | NM_001081242 | |||||||||||
| RefSeq (protein) | NP_055874 | NP_001074711 | |||||||||||
| Location (UCSC) | Chr 15: 62.68 – 63.14 Mb | Chr 9: 67.22 – 67.56 Mb | |||||||||||
| PubMed search | |||||||||||||
Talin 2 is a protein in humans that is encoded by the TLN2 gene. It belongs to the talin protein family. This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton.[1]
References
- ↑ "Entrez Gene: Talin 2". Retrieved 2012-06-20T00:24:38.839152-08:00.
Further reading
- Anthis, N. J.; Wegener, K. L.; Critchley, D. R.; Campbell, I. D. (2010). "Structural Diversity in Integrin/Talin Interactions". Structure 18 (12): 1654–1666. doi:10.1016/j.str.2010.09.018. PMC 3157975. PMID 21134644.
- Shoeman, R. L.; Hartig, R.; Hauses, C.; Traub, P. (2002). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease". Cell biology international 26 (6): 529–539. doi:10.1006/cbir.2002.0895. PMID 12119179.
- Critchley, D. R.; Holt, M. R.; Barry, S. T.; Priddle, H.; Hemmings, L.; Norman, J. (1999). "Integrin-mediated cell adhesion: The cytoskeletal connection". Biochemical Society symposium 65: 79–99. PMID 10320934.
- Di Paolo, G.; Pellegrini, L.; Letinic, K.; Cestra, G.; Zoncu, R.; Voronov, S.; Chang, S.; Guo, J.; Wenk, M. R.; De Camilli, P. (2002). "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin". Nature 420 (6911): 85–89. doi:10.1038/nature01147. PMID 12422219.
- Zemljic-Harpf, A.; Manso, A. M.; Ross, R. S. (2009). "Vinculin and talin: Focus on the myocardium". Journal of investigative medicine : the official publication of the American Federation for Clinical Research 57 (8): 849–855. doi:10.231/JIM.0b013e3181c5e074. PMC 2810504. PMID 19952892.
- Ling, K.; Doughman, R. L.; Firestone, A. J.; Bunce, M. W.; Anderson, R. A. (2002). "Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions". Nature 420 (6911): 89–93. doi:10.1038/nature01082. PMID 12422220.
- Xiao, F.; Chen, D.; Lu, Y.; Xiao, Z.; Guan, L. F.; Yuan, J.; Wang, L.; Xi, Z. Q.; Wang, X. F. (2009). "Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy". Brain Research 1255: 180–189. doi:10.1016/j.brainres.2008.12.008. PMID 19109932.
- Critchley, D. R. (2004). "Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion". Biochemical Society Transactions 32 (5): 831–836. doi:10.1042/BST0320831. PMID 15494027.
- Vyas, Y. M.; Maniar, H.; Dupont, B. (2002). "Cutting edge: Differential segregation of the SRC homology 2-containing protein tyrosine phosphatase-1 within the early NK cell immune synapse distinguishes noncytolytic from cytolytic interactions". Journal of immunology (Baltimore, Md. : 1950) 168 (7): 3150–3154. PMID 11907066.
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