TGS1

From Wikipedia, the free encyclopedia

Trimethylguanosine synthase 1

Rendering based on PDB 3GDH.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3EGI, 3GDH

Identifiers

Symbols

TGS1; NCOA6IP; PIMT; PIPMT

External IDs

OMIM: 606461 MGI: 2151797 HomoloGene: 32608 GeneCards: TGS1 Gene

EC number

2.1.1.-

Gene Ontology
Molecular function	• RNA trimethylguanosine synthase activity
Cellular component	• nucleus • nucleoplasm • cytoplasm • cytosol • Cajal body • small nuclear ribonucleoprotein complex
Biological process	• spliceosomal snRNP assembly • RNA methylation • transcription, DNA-dependent • regulation of transcription, DNA-dependent • 7-methylguanosine RNA capping • gene expression • RNA metabolic process • ribonucleoprotein complex biogenesis • ncRNA metabolic process • 7-methylguanosine cap hypermethylation • cellular lipid metabolic process • small molecule metabolic process • ribonucleoprotein complex import into nucleus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
56.69 – 56.74 Mb

Chr 4:
3.57 – 3.62 Mb

PubMed search

Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.^[1]^[2]^[3]

Interactions

TGS1 has been shown to interact with NCOA6,^[1]^[4] MED1,^[4] EP300,^[4] CREB-binding protein^[4] and EED.^[5]

References

↑ 1.0 1.1 Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (Aug 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc Natl Acad Sci U S A 98 (18): 10380–5. doi:10.1073/pnas.181347498. PMC 56969. PMID 11517327.
↑ Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonne R (May 2002). "Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus". Mol Cell 9 (4): 891–901. doi:10.1016/S1097-2765(02)00484-7. PMID 11983179.
↑ "Entrez Gene: TGS1 trimethylguanosine synthase homolog (S. cerevisiae)".
↑ 4.0 4.1 4.2 4.3 Misra, Parimal; Qi Chao, Yu Songtao, Shah Sejal H, Cao Wen-Qing, Rao M Sambasiva, Thimmapaya Bayar, Zhu Yijun, Reddy Janardan K (May 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. (United States) 277 (22): 20011–9. doi:10.1074/jbc.M201739200. ISSN 0021-9258. PMID 11912212. Cite uses deprecated parameters (help)
↑ Enünlü, Izzet; Pápai Gábor, Cserpán Imre, Udvardy Andor, Jeang Kuan-Teh, Boros Imre (Sep 2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. (United States) 309 (1): 44–51. doi:10.1016/S0006-291X(03)01514-6. ISSN 0006-291X. PMID 12943661. Cite uses deprecated parameters (help)

Misra P, Qi C, Yu S et al. (2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.
Verheggen C, Lafontaine DL, Samarsky D et al. (2002). "Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments". EMBO J. 21 (11): 2736–45. doi:10.1093/emboj/21.11.2736. PMC 126019. PMID 12032086.
Wang Y, Han KJ, Pang XW et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. PMID 12097419.
Surapureddi S, Yu S, Bu H et al. (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. doi:10.1073/pnas.182426699. PMC 129355. PMID 12189208.
Krackhardt AM, Witzens M, Harig S et al. (2002). "Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX". Blood 100 (6): 2123–31. doi:10.1182/blood-2002-02-0513. PMID 12200376.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mouaikel J, Narayanan U, Verheggen C et al. (2004). "Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron". EMBO Rep. 4 (6): 616–22. doi:10.1038/sj.embor.embor863. PMC 1319203. PMID 12776181.
Enünlü I, Pápai G, Cserpán I et al. (2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/S0006-291X(03)01514-6. PMID 12943661.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Watkins NJ, Lemm I, Ingelfinger D et al. (2005). "Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex". Mol. Cell 16 (5): 789–98. doi:10.1016/j.molcel.2004.11.012. PMID 15574333.
Oh JH, Yang JO, Hahn Y et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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TGS1

Interactions

References

Further reading