TEC (gene)

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Tec protein tyrosine kinase

PDB rendering based on 1gl5.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsTEC; PSCTK4
External IDsOMIM: 600583 MGI: 98662 HomoloGene: 1302 ChEMBL: 4246 GeneCards: TEC Gene
EC number2.7.10.2
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez700621682
EnsemblENSG00000135605ENSMUSG00000029217
UniProtP42680P24604
RefSeq (mRNA)NM_003215NM_001113460
RefSeq (protein)NP_003206NP_001106931
Location (UCSC)Chr 4:
48.14 – 48.27 Mb		Chr 5:
72.76 – 72.87 Mb
PubMed search
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Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.[1][2]

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.[2]

Interactions

TEC (gene) has been shown to interact with GNA12,[3] Janus kinase 2,[4][5] CD117,[6][7] Suppressor of cytokine signaling 1,[8] ARHGEF12[3] and DOK1.[6][9]

References

  1. ↑ Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (November 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia 8 (10): 1663–72. PMID 7934162. 
  2. ↑ 2.0 2.1 "Entrez Gene: TEC tec protein tyrosine kinase". 
  3. ↑ 3.0 3.1 Suzuki, Nobuchika; Nakamura Susumu, Mano Hiroyuki, Kozasa Tohru (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. doi:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866. 
  4. ↑ Takahashi-Tezuka, M; Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene (ENGLAND) 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. ISSN 0950-9232. PMID 9178903. 
  5. ↑ Yamashita, Y; Watanabe S, Miyazato A, Ohya K i, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H (March 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood (UNITED STATES) 91 (5): 1496–507. ISSN 0006-4971. PMID 9473212. 
  6. ↑ 6.0 6.1 van Dijk, T B; van Den Akker E, Amelsvoort M P, Mano H, Löwenberg B, von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood (UNITED STATES) 96 (10): 3406–13. ISSN 0006-4971. PMID 11071635. 
  7. ↑ Tang, B; Mano H, Yi T, Ihle J N (December 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Mol. Cell. Biol. (UNITED STATES) 14 (12): 8432–7. ISSN 0270-7306. PMC 359382. PMID 7526158. 
  8. ↑ Ohya, K i; Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H (October 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. (UNITED STATES) 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. ISSN 0021-9258. PMID 9341160. 
  9. ↑ Liang, Xiquan; Wisniewski David, Strife Annabel, Shivakrupa , Clarkson Bayard, Resh Marilyn D (April 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". J. Biol. Chem. (United States) 277 (16): 13732–8. doi:10.1074/jbc.M200277200. ISSN 0021-9258. PMID 11825908. 

Further reading

  • Mano H (2000). "Tec family of protein-tyrosine kinases: an overview of their structure and function". Cytokine Growth Factor Rev. 10 (3–4): 267–80. doi:10.1016/S1359-6101(99)00019-2. PMID 10647781. 
  • Yang WC, Collette Y, Nunès JA, Olive D (2000). "Tec kinases: a family with multiple roles in immunity". Immunity 12 (4): 373–82. doi:10.1016/S1074-7613(00)80189-2. PMID 10795735. 
  • Mano H, Ishikawa F, Nishida J et al. (1991). "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver". Oncogene 5 (12): 1781–6. PMID 2284097. 
  • Tang B, Mano H, Yi T, Ihle JN (1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Mol. Cell. Biol. 14 (12): 8432–7. PMC 359382. PMID 7526158. 
  • Machide M, Mano H, Todokoro K (1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene 11 (4): 619–25. PMID 7651724. 
  • Mano H, Yamashita Y, Miyazato A et al. (1996). "Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase". FASEB J. 10 (5): 637–42. PMID 8621063. 
  • Rawlings DJ, Scharenberg AM, Park H et al. (1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science 271 (5250): 822–5. doi:10.1126/science.271.5250.822. PMID 8629002. 
  • Park H, Wahl MI, Afar DE et al. (1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain". Immunity 4 (5): 515–25. doi:10.1016/S1074-7613(00)80417-3. PMID 8630736. 
  • Ohta Y, Haire RN, Amemiya CT et al. (1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene 12 (4): 937–42. PMID 8632917. 
  • Cory GO, MacCarthy-Morrogh L, Banin S et al. (1996). "Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways". J. Immunol. 157 (9): 3791–5. PMID 8892607. 
  • Takahashi-Tezuka M, Hibi M, Fujitani Y et al. (1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903. 
  • Laffargue M, Monnereau L, Tuech J et al. (1997). "Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets". Biochem. Biophys. Res. Commun. 238 (1): 247–51. doi:10.1006/bbrc.1997.7269. PMID 9299487. 
  • Ohya K, Kajigaya S, Yamashita Y et al. (1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID 9341160. 
  • Kitanaka A, Mano H, Conley ME, Campana D (1998). "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells". Blood 91 (3): 940–8. PMID 9446655. 
  • Yamashita Y, Watanabe S, Miyazato A et al. (1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood 91 (5): 1496–507. PMID 9473212. 
  • Yang WC, Ghiotto M, Barbarat B, Olive D (1999). "The role of Tec protein-tyrosine kinase in T cell signaling". J. Biol. Chem. 274 (2): 607–17. doi:10.1074/jbc.274.2.607. PMID 9872994. 
  • Yang WC, Olive D (1999). "Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway". Eur. J. Immunol. 29 (6): 1842–9. doi:10.1002/(SICI)1521-4141(199906)29:06<1842::AID-IMMU1842>3.0.CO;2-D. PMID 10382746. 
  • Ohya K, Kajigaya S, Kitanaka A et al. (1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11976–81. doi:10.1073/pnas.96.21.11976. PMC 18397. PMID 10518561. 


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