TARBP2

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TAR (HIV-1) RNA binding protein 2

PDB rendering based on 2cpn.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsTARBP2; LOQS; TRBP; TRBP1; TRBP2
External IDsOMIM: 605053 MGI: 103027 HomoloGene: 7562 ChEMBL: 2098 GeneCards: TARBP2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez689521357
EnsemblENSG00000139546ENSMUSG00000023051
UniProtQ15633P97473
RefSeq (mRNA)NM_004178NM_001253795
RefSeq (protein)NP_004169NP_001240724
Location (UCSC)Chr 12:
53.89 – 53.9 Mb
Chr 15:
102.52 – 102.52 Mb
PubMed search

RISC-loading complex subunit TARBP2 is a protein that in humans is encoded by the TARBP2 gene.[1][2]

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.[2]

Interactions

TARBP2 has been shown to interact with Protein kinase R[3][4] and RBM14.[5]

References

  1. Gatignol A, Buckler-White A, Berkhout B, Jeang KT (May 1991). "Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR". Science 251 (5001): 1597–600. doi:10.1126/science.2011739. PMID 2011739. 
  2. 2.0 2.1 "Entrez Gene: TARBP2 Tar (HIV-1) RNA binding protein 2". 
  3. Cosentino, G P; Venkatesan S, Serluca F C, Green S R, Mathews M B, Sonenberg N (October 1995). "Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (21): 9445–9. doi:10.1073/pnas.92.21.9445. ISSN 0027-8424. PMC 40818. PMID 7568151. 
  4. Daher, A; Longuet M, Dorin D, Bois F, Segeral E, Bannwarth S, Battisti P L, Purcell D F, Benarous R, Vaquero C, Meurs E F, Gatignol A (September 2001). "Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression". J. Biol. Chem. (United States) 276 (36): 33899–905. doi:10.1074/jbc.M103584200. ISSN 0021-9258. PMID 11438532. 
  5. Iwasaki, T; Chin W W, Ko L (September 2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. (United States) 276 (36): 33375–83. doi:10.1074/jbc.M101517200. ISSN 0021-9258. PMID 11443112. 

Further reading


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