Syntaxin 3
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| Syntaxin 3 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | STX3; STX3A | ||||||||||||
| External IDs | OMIM: 600876 MGI: 103077 HomoloGene: 80191 GeneCards: STX3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6809 | 20908 | |||||||||||
| Ensembl | ENSG00000166900 | ENSMUSG00000041488 | |||||||||||
| UniProt | Q13277 | Q64704 | |||||||||||
| RefSeq (mRNA) | NM_001178040 | NM_001025307 | |||||||||||
| RefSeq (protein) | NP_001171511 | NP_001020478 | |||||||||||
| Location (UCSC) | Chr 11: 59.48 – 59.57 Mb | Chr 19: 11.78 – 11.82 Mb | |||||||||||
| PubMed search | |||||||||||||
Syntaxin 3, also known as STX3, is a protein[1] which in humans is encoded by the STX3 gene.[2][3]
Function
The protein encoded by this gene is a member of the syntaxin family of cellular receptors for transport vesicles which participate in exocytosis in neutrophils.[2] STX3 has an important role in the growth of neurites and serves as a direct target for omega-6 arachidonic acid.[4]
Interactions
Syntaxin 3 has been shown to interact with SNAP-25,[5][6][7] SNAP23[6][7][8][9] and SNAP29.[7]
References
- ↑ Ibaraki K, Horikawa HP, Morita T, Mori H, Sakimura K, Mishina M, Saisu H, Abe T (June 1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732.
- ↑ 2.0 2.1 Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (March 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol. 65 (3): 397–406. PMID 10080545.
- ↑ "Entrez Gene: STX3 syntaxin 3".
- ↑ Darios F, Davletov B (April 2006). "Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3". Nature 440 (7085): 813–7. Bibcode:2006Natur.440..813D. doi:10.1038/nature04598. PMID 16598260.
- ↑ Hata, Y; Südhof T C (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. (UNITED STATES) 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. ISSN 0021-9258. PMID 7768895.
- ↑ 6.0 6.1 Ravichandran, V; Chawla A, Roche P A (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. (UNITED STATES) 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. ISSN 0021-9258. PMID 8663154.
- ↑ 7.0 7.1 7.2 Steegmaier, M; Yang B, Yoo J S, Huang B, Shen M, Yu S, Luo Y, Scheller R H (Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. (UNITED STATES) 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. ISSN 0021-9258. PMID 9852078.
- ↑ Imai, Akane; Nashida Tomoko, Yoshie Sumio, Shimomura Hiromi (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. (England) 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. ISSN 0003-9969. PMID 12828989.
- ↑ Araki, S; Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. (UNITED STATES) 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. ISSN 0006-291X. PMID 9168999.
Further reading
- Ibaraki K, Horikawa HP, Morita T, et al. (1995). "Identification of four different forms of syntaxin 3.". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732.
- Hata Y, Südhof TC (1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic.". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
- Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.". Nature 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID 7791877.
- Morgans CW, Brandstätter JH, Kellerman J, et al. (1996). "A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retina.". J. Neurosci. 16 (21): 6713–21. PMID 8824312.
- Tellam JT, Macaulay SL, McIntosh S, et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4.". J. Biol. Chem. 272 (10): 6179–86. doi:10.1074/jbc.272.10.6179. PMID 9045631.
- Delgrossi MH, Breuza L, Mirre C, et al. (1997). "Human syntaxin 3 is localized apically in human intestinal cells.". J. Cell. Sci. 110 (18): 2207–14. PMID 9378770.
- Galli T, Zahraoui A, Vaidyanathan VV, et al. (1998). "A Novel Tetanus Neurotoxin-insensitive Vesicle-associated Membrane Protein in SNARE Complexes of the Apical Plasma Membrane of Epithelial Cells". Mol. Biol. Cell 9 (6): 1437–48. PMC 25366. PMID 9614185.
- Riento K, Galli T, Jansson S, et al. (1999). "Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells". J. Cell. Sci. 111 (17): 2681–8. PMID 9701566.
- Steegmaier M, Yang B, Yoo JS, et al. (1999). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
- Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol. 65 (3): 397–406. PMID 10080545.
- Fasshauer D, Antonin W, Margittai M, et al. (1999). "Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties". J. Biol. Chem. 274 (22): 15440–6. doi:10.1074/jbc.274.22.15440. PMID 10336434.
- Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and Biochemical Analysis of the C2 Domains of Synaptotagmin IV". Mol. Biol. Cell 10 (7): 2285–95. PMC 25443. PMID 10397765.
- Riento K, Kauppi M, Keranen S, Olkkonen VM (2000). "Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells". J. Biol. Chem. 275 (18): 13476–83. doi:10.1074/jbc.275.18.13476. PMID 10788461.
- Kauppi M, Wohlfahrt G, Olkkonen VM (2003). "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3". J. Biol. Chem. 277 (46): 43973–9. doi:10.1074/jbc.M208315200. PMID 12198139.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Imai A, Nashida T, Yoshie S, Shimomura H (2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Bandyopadhyay BC, Swaim WD, Liu X, et al. (2005). "Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx". J. Biol. Chem. 280 (13): 12908–16. doi:10.1074/jbc.M410013200. PMID 15623527.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
- Low SH, Vasanji A, Nanduri J, et al. (2006). "Syntaxins 3 and 4 Are Concentrated in Separate Clusters on the Plasma Membrane before the Establishment of Cell Polarity". Mol. Biol. Cell 17 (2): 977–89. doi:10.1091/mbc.E05-05-0462. PMC 1356605. PMID 16339081.
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