Sunepitron

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Sunepitron
Systematic (IUPAC) name
1-{[2-(pyrimidin-2-yl)octahydro-2H-pyrido[1,2-a]pyrazin-7-yl]methyl}pyrrolidine-2,5-dione
Clinical data
Legal status Uncontrolled
Routes Oral
Identifiers
CAS number 148408-65-5
ATC code None
PubChem CID 9799246
ChemSpider 7975011
UNII 2GT50C8U60 YesY
KEGG D02569
ChEMBL CHEMBL380369
Chemical data
Formula C17H23N5O2 
Mol. mass 329.40 g/mol

Sunepitron (CP-93,393) is a combined 5-HT1A receptor agonist and α2-adrenergic receptor antagonist.[1][2] It was previously under development by Pfizer for the treatment of depression and anxiety.[3] It made it to phase III clinical trials before being discontinued.[2][3]

Synthesis

Sunepitron can be synthesized from a pyridine dicarboxylic acid:[4]

See also

References

  1. ↑ Goodnick PJ (July 1999). "Psychopharmacology of depression in the next millennium". CNS Spectrums 4 (7): 21–35. PMID 18438295. 
  2. ↑ 2.0 2.1 Stahl, S. M. (2000). Essential psychopharmacology: neuroscientific basis and practical application. Cambridge, UK: Cambridge University Press. ISBN 0-521-64615-4. 
  3. ↑ 3.0 3.1 Kaplan, Eliot F.; Turkington, Carol (2001). Making the antidepressant decision: how to choose the right treatment option for you and your loved ones. Chicago, Ill: Contemporary Books. ISBN 0-7373-0417-0. 
  4. ↑ G.N. Bright, K.A. Desai, U.S. Patent 5,122,525 (1992)
Anxiolytics (N05B)
GABAA
PAMs
non-N05B
α2δ VDCC Blockers
5-HT1A Agonists
H1 Antagonists
CRH1 Antagonists
NK2 Antagonists
MCH1 antagonists
mGluR2/3 Agonists
mGluR5 NAMs
TSPO agonists
σ1 agonists
Antidepressants
Others

M: PSO/PSI

mepr

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc (eval/thrp), drug (N5A/5B/5C/6A/6B/6D)

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