Sulforhodamine 101

Sulforhodamine 101
Identifiers
CAS number	60311-02-6 Y
PubChem	122180
	Beilstein Reference	3582548
Jmol-3D images	{{#if:[O-]S(C(C=C(S(O)(=O)=O)C=C1)=C1C2=C(C=C3C4=C5CCCN4CCC3)C5=[O+]C6=C(CCCN7CCC8)C7=C8C=C62)(=O)=O|Image 1
SMILES [O-]S(C(C=C(S(O)(=O)=O)C=C1)=C1C2=C(C=C3C4=C5CCCN4CCC3)C5=[O+]C6=C(CCCN7CCC8)C7=C8C=C62)(=O)=O
Properties
Molecular formula	C31H30N2O7S2
Molar mass	606.71 g mol−1
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Sulforhodamine 101 is a red fluorescent dye. In neurophysiological experiments which comprise calcium imaging methods, it can be used for a counterstaining of astrocytes to be able to analyze data from neurons separately.^[1] Sulforhodamine 101 has been reported to affect excitability of neurons and should therefore be used with caution.^[2]

A sulfonyl chloride derivative of sulforhodamine 101, known as Texas Red, is used for conjugation to a number of functional groups, especially primary amines.

References

1. ↑ Nimmerjahn, A.; Kirchhoff, F.; Kerr, J.N.; Helmchen, F. (2004). "Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo". Nature Methods 1 (1): 31–7. doi:10.1038/nmeth706. PMID 15782150. 
2. ↑ Kang, J.; Kang N.; Yu, Y.; Zhang, J.; Petersen, N.; Tian G.-F.; Nedergaard, M. (2010). "Sulforhodamine 101 induces long-tem potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons". Neuroscience 169 (4): 1601–1609. doi:10.1016/j.neuroscience.2010.06.020. PMID 2918738.