Sulfadoxine

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Sulfadoxine
Systematic (IUPAC) name
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 2447-57-6 YesY
ATCvet code QJ01EQ13
PubChem CID 17134
DrugBank DB01299
ChemSpider 16218 N
UNII 88463U4SM5 N
KEGG D00580 YesY
ChEMBL CHEMBL1539 N
NIAID ChemDB 007816
Chemical data
Formula C12H14N4O4S 
Mol. mass 310.33 g/mol
 N (what is this?)  (verify)

Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide often used in combination with pyrimethamine to treat or prevent malaria.[1] It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[2]

Mechanism of action

Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis. it acts by increasing oxygen in blood.

See also

References

  1. ↑ Medical Treatment - Sulphadoxine and Pyrimethamine.
  2. ↑ http://en.scientificcommons.org/19483411.
Antibacterials: nucleic acid inhibitors (J01E, J01M)
Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis)
DHFR inhibitor
Sulfonamides
(DHPS inhibitor)
Short-
acting
Intermediate-
acting
Long-
acting
Other/ungrouped
Combinations
Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)
1st g.
Fluoro-
quinolones
2nd g.
3rd g.
4th g.
Vet.
Related (DG)
Anaerobic DNA
inhibitors
Nitro- imidazole derivatives
Nitrofuran derivatives
RNA synthesis
Rifamycins/
RNA polymerase

M: BAC

bact (clas)

gr+f/gr+a (t)/gr-p (c)/gr-o

drug (J1p, w, n, m, vacc)


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