Stibophen

Stibophen

Systematic (IUPAC) name
Pentasodium 2-(2-oxido-3,5-disulfonatophenoxy)-1,3,2-benzodioxastibole-5,7-disulfonate
Clinical data
Legal status	?
Identifiers
CAS number	23940-36-5
ATC code	P02BX03
PubChem	CID 16683091
Chemical data
Formula	C12H4Na5O16S4Sb
Mol. mass	769.12 g/mol
SMILES C1=C(C=C2C(=C1S(=O)(=O)[O-])O[Sb](O2)OC3=CC(=CC(=C3[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+]
Y (what is this?)  (verify)

Stibophen is an anthelmintic classified as antimony compound and used as treatment of schistosomiasis^[1] by intramuscular injection.

Mechanism of action

Stibophen inhibits the enzyme phosphofructokinase, which the worms need for glycolysis,^[2] at least partly by binding to the sulfhydryl (–SH) group of the enzyme.^[3] Inhibiting glycolysis paralyzes the worms, which lose their hold on the wall of mesenteric veins and undergo hepatic shift, die, and are phagocytosed by liver cells.^{[citation needed]}

References