Sorivudine

Sorivudine

Systematic (IUPAC) name
1-β-D-arabinofuranosyl-5-[(E)-2-bromovinyl]pyrimidine-2,4(1H,3H)-dione
Clinical data
Legal status	?
Routes	oral
Pharmacokinetic data
Metabolism	Viral thymidine kinase
Excretion	kidney
Identifiers
CAS number	77181-69-2 Y
ATC code	J05AB15
PubChem	CID 5282192
UNII	C7VOZ162LV N
KEGG	D01734 Y
ChEMBL	CHEMBL375035 N
Synonyms	BV-araU, Bromovinyl araU, 5-Bromovinyl-araU, 5-[(E)-2-bromoethenyl]-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Chemical data
Formula	C11H13BrN2O6
Mol. mass	349.14 g/mol
N (what is this?)  (verify)

Sorivudine (INN) chemical name (E)-5-(2-Bromovinyl)- 1β-D-arabinofuranosyluracil, is a thymine analogue antiviral drug, marketed under trade names such as Usevir (Nippon Shoji, Eisai) and Brovavir (BMS).

Pharmacology

Feature

• First-line treatment of herpes drug acyclovir was (Zovirax, Activir) from VZV strong activity of the virus.
• Superior gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted as urine.

Mechanism of action

• Sorivudine is phosphorylated by thymidine kinase activity in the body and is absorbed into the virus's DNA, to inhibit viral DNA replication of DNA polymerase to make it fail to inhibit viral growth.

Microbiology

Sorivudine is active against most species in the herpesvirus family.

• Herpes simplex virus type I (HSV-1)
• Varicella zoster virus (VZV)
• Epstein-Barr virus (EBV)