Sonic spray ionization

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Sonic spray ionization (SSI) is a method for creating ions from a liquid solution, for example, a mixture of methanol and water. A pneumatic nebulizer is used to turn the solution into a supersonic spray of small droplets. Ions are formed when the solvent evaporates and the statistically unbalanced charge distribution on the droplets leads to a net charge. Complete desolvation results in ions that can be detected using mass spectrometry.[1]

Applications

Sonic spray ionization has been coupled with high performance liquid chromatography for the analysis of drugs.[2][3] Oligonucleotides have been studied with this method.[4][5] SSI has been used in a manner similar to desorption electrospray ionization[6] for ambient ionization and has been couplet with thin layer chromatography in this manner.[7]

See also

References

  1. ↑ Hirabayashi A, Sakairi M, Koizumi H (1995). "Sonic spray mass spectrometry". Anal. Chem. 67 (17): 2878–2882. doi:10.1021/ac00113a023. PMID 8779414. 
  2. ↑ Arinobu T, Hattori H, Seno H, Ishii A, Suzuki O (2002). "Comparison of SSI with APCI as an interface of HPLC-mass spectrometry for analysis of a drug and its metabolites". J. Am. Soc. Mass Spectrom. 13 (3): 204–208. doi:10.1016/S1044-0305(01)00359-2. PMID 11908800. 
  3. ↑ Dams R, Benijts T, Günther W, Lambert W, De Leenheer A (2002). "Sonic spray ionization technology: performance study and application to a LC/MS analysis on a monolithic silica column for heroin impurity profiling". Anal. Chem. 74 (13): 3206–3212. doi:10.1021/ac0112824. PMID 12141684. 
  4. ↑ Huang M, Hirabayashi A, Okumura A, Hirabayashi Y (2001). "Matrix effect on the analysis of oligonucleotides by using a mass spectrometer with a sonic spray ionization source". Anal Sci 17 (10): 1179–1182. doi:10.2116/analsci.17.1179. PMID 11990592. 
  5. ↑ Huang M, Hirabayashi A (2002). "Multi-charged oligonucleotide ion formation in sonic spray ionization". Anal Sci 18 (4): 385–390. doi:10.2116/analsci.18.385. PMID 11999509. 
  6. ↑ Haddad R, Sparrapan R, Eberlin MN (2006). "Desorption sonic spray ionization for (high) voltage-free ambient mass spectrometry". Rapid Commun. Mass Spectrom. 20 (19): 2901–2905. doi:10.1002/rcm.2680. PMID 16941547. 
  7. ↑ Haddad R, Milagre HM, Catharino RR, Eberlin MN (2008). "Easy Ambient Sonic-Spray Ionization Mass Spectrometry Combined with Thin-Layer Chromatography". Anal. Chem. 80 (8): 2744–2750. doi:10.1021/ac702216q. PMID 18331004. 
Ion source
Mass analyzer
Detector
MS combination
Fragmentation
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