Sohrab Rohani

Dr. Sohrab Rohani, Professor and former Chair, Department of Chemical and Biochemical Engineering at Western University was named a recipient of the Engineering Medal – Research and Development Category.^[1]

Professor Rohani’s main areas of research are Crystallization of Pharmaceuticals (polymorphism) and Process Control.

Education

• B.Sc. (Shiraz University, Iran) 1973
• Ph.D. (University of Wales, Britain) 1977 ^[2]

Recent Publications

• Sabouni, R; Kazemian, H. and S. Rohani, Mathematical Modeling and Experimental Breakthrough Curves of Carbon Dioxide Adsorption on Metal Organic Framework CPM-5, Environmental Science & Technology, accepted June 2013.
• Ragab, D. and S. Rohani, Cubic magnetically guided nanoaggregates for inhalable anticancer drug delivery: In vitro magnetic aerosol deposition study, AAPS PharmSciTech, (DOI) 10.1208/s12249-013-9980-y, accepted May 2013 (impact factor 1.43).
• Dehnavi, V.; Luan, B.; Shoesmith, D.; Liu, X.Y. and S. Rohani, Effect of duty cycle and applied current frequency on plasma electrolytic oxidation (PEO) coating growth behavior, Surface and Coatings Technology, Ms. Ref. No.: SURFCOAT-D-13-00119R1, accepted March 2013.
• Sabouni, R; Kazemian, H. and S. Rohani, Carbon Dioxide Adsorption in Microwave- Synthesized Metal Organic Framework CPM-5: Equilibrium and Kinetics study, Microporous & Mesoporous Materials, 175(July) 85-91 (2013).
• Sheikholeslamzadeh, E. and S. Rohani, Modeling and Optimal Control of Solution Mediated Polymorphic Transformation of L-glutamic Acid, I&ECR, 52(7), 2633-2641(2013) (impact factor 2.01).

• Mirmehrabi, M. and S. Rohani, Corrections for "Thermodynamic Modeling of Activity Coefficient and Prediction of Solubility. Parts1 and 2", Journal of Pharmaceutical Sciences vol 95, No 4, 2006, pages 790-809", J. Pharm. Sci., 102(3), 786 (2013).

• Hossein Kazemian, H.; Turowec, B.; Siddiquee, M.N. and S. Rohani, Biodiesel Production Using Cesium Modified Mesoporous Ordered Silica as Heterogeneous Base Catalyst, Fuel, 103, 719-724 (2013). (impact factor=3.248).
• Sheikholeslamzadeh, E.; Chen, C-C; and S. Rohani, Optimal Solvent Screening for the Crystallization of Pharmaceutical Compounds from Multi-solvent Systems, I&ECR, 51(42), 13792-13802 (2012).
• Wu, L.; Beaurgard, Y.; Qin, Z.; Rohani, S. and D. W. Shoesmith, A model for the influence of steel corrosion products on nuclear fuel under permanent disposal conditions, Corrosion Sci. (61), 83-91 (2012) . (impact factor=3.734).
• Lu, J.; Yi-Ping Li, Y-P; Wang, J.; Li, Z.; Rohani, S. and C-B Ching, Crystallization of an active pharmaceutical ingredient that oils out. Separation and Purification Technology, (96), 1-6 (2012). (impact factor=2.921).
• Mao, S.; Zhang, Y.; Rohani, S. and A. K. Ray, Chromatographic Resolution and Isotherm Determination of (R,S)-Mandelic Acid on Chiralcel-OD Column, Journal of Separation Science, 35(17), 2273-2281 (2012). (impact factor=2.733).
• Ragab, D; Rohani, S. and S. Consta, Controlled Release of 5-Fluorouracil and Progesterone from Magnetic Nano-Aggregates, Int. J. Nanomed., (7) 3167-3189 (2012) (impact factor=4.976).
• Lu, J.; Wang, J.; Li, Z. and S. Rohani, Characterization and pseudopolymorphism of L-phenylalanine anhydrous and monohydrate forms. African Journal of Pharmacy and Pharmacology, 6(4), 269-277 (2012).
• Lu, Jie; Li, Yi-Ping; Li, Q; Li, Z; and S. Rohani, Sohrab, Solubility of L-Phenylamine Anhydrous and Monohydrate Forms: Experimental Measurements and Prediction, CJ. Chem. & Eng. Data 57(5), 1492-1498 (2012).
• Trifkovic, M.; Rohani, S. and M. Sheikhzadeh, Kinetics Estimation and Polymorphic Transformation Modeling of Buspirone Hydrochloride, J. Cryst. Process Technol., 2(2), 31-43 (2012).
• Zhao, Yingying; Yuan, Junsheng; ji, zhiyong; Wang, Jingkang; ROHANI, S, The Combined Application of in-situ FBRM, ATR-FTIR and Raman on Polymorphism Transformation Monitoring during the Cooling Crystallization, I&ECR, 51(38), 12530-12536 (2012).
• Sheikholeslamzadeh, E. and S. Rohani, FPE-D-12-00237R1, Vapour-Liquid and Vapour-Liquid-Liquid Equilibrium Modeling for Binary, Ternary, and Quaternary Systems of solvents Fluid Phase Equilibria, Fluid Phase Equilibria (333) 97-105 (2012). (impact factor=2.139).
• Rohani, S.; Isimjan, T.; Mohamed, A.; Kazemian, H.; Salem, M and T. Wang, Fabrication, modification and environmental applications of TiO2 nanotube arrays (TNTAs) and nanoparticles, Frontiers of Chem. Eng., 6(11), 112-122 (2012).
• Peng, Y.; He, Q.; Rohani, S. and H. Jenkins, Resolution of 2-chloromandelic acid with (R)-(+)-N-Benzyl-1-Phenylethylamine: Chiral Discrimination Mechanism, Chirality, 24(5), 349-355 (2012). (impact factor= 2.892).
• Herrera, J. E.; Isimjan, T. T.; Abdullahi, I.; Ray, A. K. and S. Rohani, A novel nanoengineered VOx catalyst supported on highly ordered TiO2 nanotube arrays for partial oxidation reactions, Applied Catal. A, 417-418, 13-18 (2012).
• Isimjan, T.; Zhu Yan; D.-Q Yang; S. Rohani and A. K. Ray, A new approach of tailoring wetting properties of TiO2 nanotubular surfaces, Advanced Sci Letters, 18, 158-163 (2012). (impact factor=1.25).
• Isimjan, T.; Wang, T.; and S. Rohani, A Novel Method to Prepare Superhydrophobic, UV Resistance and Anti-corrosion" has been accepted for publication in Chemical Engineering Journal, 210, 182-187 (2012) . (impact factor=3.461).
• Gordon, J.; Kazemian, H. and S. Rohani, Rapid and efficient crystallization of MIL-53(Fe) by ultrasound and microwave irradiation, Microporous & Mesoporous Materials, 162, 36–43 (2012).
• Ahmadi, S.; M. Manteghian; H. Kazemian; S. Rohani; J. Towfighi Darian, Synthesis of silver nano catalyst by gel-casting using response surface methodology, Powder Technol., 228,163-170, (2012).
• Lu, J.; Yi-Ping Li, Y-P; Wang, J.; Li, Z.; Rohani, S. and C-B Ching, Study on the oiling-out and crystallization for the purification of idebenone, Organic Process Research & Development, 16(3), 442-446 (2012).
• Lu, J.; Wang, J. and S. Rohani, Preparation and characterization of amorphous, I and II forms of clopidogrel hydrogen sulfate. Crystal Research and Technology, 47(5), 505-510 (2012).
• Zhao, Y. Y.; Sohrab Rohani *, Y. Bao, J.k. Wang *, Characterizing the Polymorphic Transformation of Carbamazepine Using FBRM, ATR-FTIR and Raman, Pharmaceutics, 4, 164-178 (2012).
• Sheikholeslamzadeh, E. and S. Rohani, Solubility Prediction of Pharmaceutical and Chemical Compounds in Pure and Mixed Solvents Using Predictive Models, I&ECR 51(1), 464-473 (2012).
• He, Q.; S. Rohani; Zhu, J. and H. Gomaa, Resolution of Sertraline with (R)-Mandelic Acid: Chiral Discrimination Mechanism Study, Chirality, 24(2), 119-128 (2012).
• Isimjan, T.; Rohani, S.; and A. K. Ray, Photoelectrochemical Water Splitting for Hydrogen Generation on Highly Ordered TiO2 Nanotubes Fabricated by Using Ti as Cathode, Int. J. Hydrogen Energy, 37(1), 103-108 (2012).
• Trifkovic M.; M. Sheikhzadeh; K. Choo and S. Rohani, Model Predictive Control of a Twin-Screw Extruder for Thermoplastic Vulcanizate (TPV) Applications, Comp. & Chem. Eng., 36, 247-254 (2012).
• Dargahi, M.; Kazemian, H.; Soltanieh, M.; Hosseinpoor,M. and S. Rohani,

High Temperature Synthesis of SAPO-34: Applying an L9 Taguchi Orthogonal Design to Investigate the Effects of Experimental Parameters, Powder Technology, (217) 223-230 (2012).

• Siddiquee, M., Kazemian, H. and S. Rohani, Lipid, Biodiesel, FAME, Mesoporous Heterogeneous Catalyst, Chem. Eng. & Technol., 34(12), 1983-1988 (2011).
• Wang, T.; X. Tao; X. Zeng; Z. Shen; J. Chen and S. Rohani, Layer-by-layer Assembly of Highly Transparent SiO2/TiO2 Coatings with Antireflection and Self-Cleaning Properties, Advanced Sci. Letters, 4(11/12), 3617-3623 (2011).
• Hu, Y.; Kazemian, H.; Roani, S.; Huang, Y. and Y. Song, In-Situ High Pressure Study of ZIF-8 by FTIR Spectroscopy, Chem. Comm., 47(47), 12694-12696 (2011).
• Lu, Jie; Jiang, Xiao-Lin; Li, Zhen; Rohani, Sohrab; Ching, Chi-Bun, Solubility of a Lysozyme in Polyelectrolyte Aqueous Solutions, J. Chem. & Eng. Data, 56(12), 4808-4812 (2011).
• Lu, Jie; Li, Yi-Ping; Wang, Jing; Li, Zhen; Rohani, Sohrab; Ching, Chi-Bun, Pharmaceutical cocrystals: a comparison of sulfamerazine with sulfamethazine, J. Crystal Growth, 335(1), 110-114 (2011).
• Dargahi, M.; H. Kazemian; M. Soltanieh and S. Rohani, Hosseinpoor, M. Rapid and Efficient High Temperature Synthesis of SAPO-34 Nano Particles Particuology, 9(5), 452-457 (2011).
• Siddiquee, M. and S. Rohani, Lipid Extraction and Biodiesel Production from Municipal Sewage Sludges - A Review, LLK1700, Fuel Process. Technol., 92, 2241-2251 (2011).
• Wang, T.; T. Isimjan; J. Chen and S. Rohani, Transparent Nanostructured Coatings with UV-shielding and Superhydrophobicity Properties, Nanotechnol., 22(26) 265708/1-265708/7, (2011) (impact factor=3.98).
• Kaliyaperumal, S.; S. Barghi; J. Zhu; L. Briens and S. Rohani, Effects of acoustic vibration on nano and sub-micron powders fluidization, Powder Technol, 9(3), 279-287 (2011).
• Kaliyaperumal, S; S. Barghi; L. Briens; S. Rohani and J. Zhu, Fluidization of nano and sub-micron powders using mechanical vibration, Powder Technol, 210(2), 143-149 (2011).
• Lu, J.; A. J. Cruz-Cabeza,; S. Rohani and M. C. Jennings, A 2:1 Sulfamethazine:Theophylline Cocrystal Exhibiting two Tautomers of Sulfamethazine, Acta Crystall. Section C, C67(8), o306-o309 (2011).
• Haja Hameed, A. S., C. Karthikeyan, G. Ravi and S. Rohani, Caharacteriation studies on the additives mixed L-arginne phosphate monohydrate (LAP) crystals, Physica B, 406, 1363-1367 (2011).
• Mohamed, A. and S. Rohani, Modified TiO2 Nanotube Arrays (TNTAs): Progressive Strategies towards Visible Light Responsive Photoanode, Energy & Envir. Sci., 4, 1065-1086 (2011).
• Isimjan, T.T.; D.-Q Yang; S. Rohani and A.K. Ray, An Innovative Approach to Synthesize Highly-Ordered TiO2 Nanotubes, J. Nanosci. & Nanotech., 11, 1079-1083 (2011).
• Siddiquee, M. and S. Rohani, Lipid Extraction and Biodiesel Production from Municipal Sewage Sludges - A Review, LLK1700, Renewable and Sustainable Energy Reviews, 15, 1067–1072 (2011).
• Lu, J.; Z. Li; X. Jiang and S. Rohani, Solubility of L-phenylalanine in aqueous solutions J. Chem. Eng. Japan, 43(8-12), 810-813 (2010).
• He, Q.; S. Rohani; J. Zhu and H. Gomaa, Crystallization of Racemic Compound and Conglomerate of (RS)-2-Chloromandelic acid, Crystal Growth & Des., 10(12), 5136-5145 (2010).
• Isimjan, T.T.; H. Kazemian; S. Rohani and A.K. Ray, Photo catalytic activities of Pt/ZIF-8 loaded highly ordered TiO2 nanotube, J. Materials Chemistry, 20(45), 10241-10245, (2010).
• Prakash, A.; A. Shukla and S. Rohani, Ultrasonic method of monitoring particle size distribution of a medium, 147, PCT Int. Appl., (2010).
• Shukla, A; A. Prakash and S. Rohani, Particle size distribution measurements in dense suspensions using ultrasonic spectroscopy with an improved model accounting for low angle scattering, AIChE J., 56(11), 2825-2837, (2010).
• Mao, S; Y. Zhang; S. Rohani and A.K. Ray, Kinetics of (R,S)- and (R)-Mandelic Acid in an Unseeded Cooling Batch Crystallizer, J. Crystal Growth, (312) 3340-3348 (2010).
• Zhang, Y; S. Mao; A. K. Ray and S. Rohani, Nucleation and Growth Kinetics of (R)-Mandelic Acid from Aqueous Solution in the Presence of Opposite Enantiomer, Crystal Growth & Des., 10(7), 2879-2887 (2010).
• Sabouni, R; H. Kazemian and S. Rohani, A novel combined manufacturing technique for rapid production of IRMOF-1 using ultrasound and microwave energies Chem. Eng. J. 165, 966-973 (2010).
• He, Q.; S. Rohani, J. Zhu and H. Gomaa, Sertraline Racemate and Enantiomer: Solid-State Characterization, Binary Phase Diagram and Crystal Structures, Crystal Growth & Des. 10(4), 1633-1645 (2010).
• Shukla, A; A. Prakash and S. Rohani, Online Measurement of Particle Size Distribution during Crystallization using Ultrasonic Spectroscopy, Chem. Engng Sci., 65(10), 3072-3079, (2010).
• Isimjan, T.T.; A.M. ElRuby; S. Rohani and A.K. Ray, Fabrication of highly-ordered and visible-light responsive Fe-C-N-codoped TiO2 nanotubes, Nanotechnol., 21(5), 055706/1-055706/6, (2010).
• Rohani, S. Applications of the Crystallization Process in the Pharmaceutical Industry, Frontiers of Chemical Engineering in China, 4(1), 2-9 (2010).
• Trifkovic M.; M. Sheikhzadeh; K. Choo and S. Rohani, Experimental and Statistical Study of the Effects of Material Properties, Curing Agents and Process Variables on the Production of hermoplastic Vulcanizates, J Applied Polymer Sci., 118(2), 764-777(2010).
• He, Q.; H. Gomaa; S. Rohani; J. Zhu and M. Jennings, Chiral Discrimination of Diastereomeric Salts of Chlorine-Substituted Mandelic Acid and Phenylethylamine, Chirality, 22(8), 707-716, (2010).
• Trifkovic M.; M. Sheikhzadeh; K. Choo and S. Rohani, Model Identification of a Twin Screw Extruder for Thermoplastic Vulcanizate (TPV) Applications, Polymer Eng. and Sci., 50(6), 1168-1177 (2010).
• Lu, J. and S. Rohani, Synthesis and preliminary characterization of sulfamethazine-theophylline co-crystal, J. Pharm. Sci. 99(9), 4042-4047 (2010).
• Ragab, D.; S. Rohani; M. W. Samaha; F. M. El-Khawas and H. A. El-Maradny, Crystallization of Progesterone for Pulmonary Drug Delivery, J. Pharm. Sci., 99(3), 1123-1137 (2010).
• He, Q.; Y. F. Peng and S. Rohani, Diastereomeric Resolution of p-Chloromandelic Acid with (R)-Phenylethylamine, Chirality, 22(1), 16-23 (2010).
• Mohamed, A. E.; N. Kasemphaibulsuk; S. Rohani and S. Barghi, Fabrication of Titania Nanotube Arrays in Viscous Electrolytes, J. Nanosci. Nanotechnol. 10 (3), 1998-2008 (2010).
• Zhang, Y.; A. K. Ray and S. Rohani; Measurement and Prediction of Phase Diagrams of the Enantiomeric 3-Chloromandelic Acid System: CES8236, Chem. Engng Sci., 64(2), 192-197 (2009).
• Trifkovic, M.; M. Sheikhzadeh and S. Rohani, Multi-Variable Real Time Optimal Control of a Cooling and Anti-solvent Semi-Batch Crystallization Process, AIChE J.,55(10), 2591-2602 (2009).
• Ragab, D. and S. Rohani, Particle Engineering Strategies via Crystallization for Pulmonary Drug Delivery, Org. Proc. Res. Dev., 13(6), 1215-1223 (2009).
• Lu, J. and S. Rohani, Polymorphism and Crystallization of the anti-viral/HIV drug stavudine, Org. Proc. Res. Dev., 13(6), 1262-1268 (2009).
• Trifkovic M.; M. Sheikhzadeh and S. Rohani, Determination of Metastable Zone Width for Combined Anti-solvent/Cooling Crystallization, J. Crystal Growth, 311(14), 3640-3650 (2009).
• Bakhbakhi, Y.; P. Charpentier and S. Rohani, The Solubility of Beclametasone-17,21dipropionate in Selected Organic Solvents: Experimental Measurements and Thermodynamic Modeling, Org. Proc. Res. Dev., 13(6), 1322-1326 (2009).
• He, Q.; J. Zhu, H. Gomaa, M. Jennings and S. Rohani, Identification and Characterization of Solid-State Nature of 2-Chloromandelic Acid, J. Pharm. Sci., 98(5), 1835-1844 (2009).
• Knox, M.; M. Trifkovic and S. Rohani, Combining Anti-Solvent and Cooling Crystallization: Effect of Solvent Composition on Yield and Meta Stable Zone Width, Chem. Engng Sci., 64, 3555-3563 (2009).
• Lu, J. and S. Rohani, Preparation and Characterization of Theophylline-Nicotinamide Cocrystal, Org. Proc. Res. Dev., 13(6) 1269-1275 (2009).
• Karami, D. and S. Rohani, Synthesis of Pure Zeolite Y Using Soluble Silicate, A Two-Level Factorial Experimental Design, Chem. Eng. and Processing, 48, 1288–1292 (2009).
• Karami, D. and S. Rohani, A Novel Approach for the Synthesis of Zeolite Y, Ind. Eng. Res. Dev., 48(10), 4837-4843 (2009).
• Lu, J. and S. Rohani, Polymorphism and Crystallization of Active Pharmaceutical Ingredients (APIs), Current Medicinal Chemistry, 16, 884-905 (2009).
• Hojjati, H. and S. Rohani, A New Approach for Isothermal Calorimetric Technique”, Reg. No.9165, J Thermal Analysis and Calorimetry, 95(1), 293–303, (2009).
• Corriou, J. P. and S. Rohani, AIChE-07-10610.R2 - A new look at optimal control of a batch crystallizer, AIChE J., 54(12), 3188-3206 (2008).
• Zhang, Y.; S. Rohani and A. K. Ray, Numerical determination of competitive adsorption isotherm of mandelic acid enantiomers on cellulose-based chiral stationary phase, JCA07-2318, J. Chromatography A, 34-39, 1202 (2008).
• Trifkovic, M.; M. Sheikhzadeh and S. Rohani, Parameter Estimation and Single/Multi - Objective Optimization of a Seeded, Anti-solvent, Isothermal Crystallizer, Ind. Eng. Res. Dev., 47, 1586-1595 (2008).
• Sheikhzadeh, M.; M. Trifkovic and S. Rohani, "Adaptive MIMO Neuro-Fuzzy Logic Control of a Seeded and an Unseeded Anti-Solvent Semi-Batch Crystallizer”, Chem. Engng Sci., 63(5), 1261-1272 (2008).
• Sheikhzadeh, M., Trifkovic M., Rohani, Real-Time Optimal Control of an Anti solvent, Isothermal Semi-Batch, Crystallizer, Chem. Engng Sci., 63(3), 829-839 (2008).
• Sheikhzadeh, M.; M. Trifkovic and S. Rohani, Fuzzy Logic and Rigid Control of a Seeded Semi-Batch, Anti solvent, Isothermal Crystallizer, Chem. Engng Sci., 63(4), 991-1002 (2008).
• He, Q.; M. C. Jennings; S. Rohani; J. Zhu and H. Gomaa, (R)-1-Phenylethanaminium (S)-4-chloromandelate, Acta Crystall., Section E, 64, o559 (2008).
• Shukla, A.; A. Prakash and S. Rohani, Particles Settling Studies Using Ultrasonic Techniques, Powder Technol. 177(2), 102-111 (2007).
• He, Q.; M. Jennings; S. Rohani; J. Zhu and H. Gomaa, R-Phenylethylammonium R-4-chloromandelate, Acta Crystall. Section E, E63(11), o4199 (2007).
• Haja Hameed, A. S.; S. Rohani; W.C. Yu; C.Y. Tai and W. C. Lan, Growth and Characterization of a New Chelating Added 4-dimethylamino-N-methyl-4-stilbazolium tosylate (DAST) single crystals, Materials Chemistry & Physics, 102(1), 60-66 (2007).

• Sarkar, D.; S. Rohani and A. Jutan, Multi-objective optimization of semi-batch reactive crystallization processes, AIChE J., 53(5), 1164-1177 (2007).
• Sheikhzadeh, M; Rohani, S; Taffish, M. and S. Murad, Solubility Analysis of Buspirone Hydrochloride Polymorphs: Measurements and Prediction, Int. J. Pharm., 338, 55-63 (2007).
• Sheikhzadeh M; Rohani S; Jutan A; Manifar T Quantitative and molecular analysis of buspirone hydrochloride polymorphs. Journal Pharmaceutical Sci., 96(3), 569-83, (2007).
• Hojjati, H.; Sheikhzadeh, M.; Rohani, S. Control of Supersaturation in a Semi-batch Antisolvent Crystallization Process Using a Fuzzy Logic Controller. Industrial & Engineering Chemistry Research 46(4), 1232-1240 (2007).
• Tifkovic, M.; S. Rohani and M. Mirmehrabi, Polymorphic generation through solvent selection: Ranitidine Hydrochloride, Org. Proc. Res. Dev., 11(1), 138-143 (2007).
• Mirmehrabi, M., S. Rohani, L. Perry, ‘Thermodynamic Modeling and Prediction of Drug Solubility in Solvents: Part 1. A New Activity Coefficient Model', J. Pharmaceutical Sci., 95(4), 790-797 (2006).
• Mirmehrabi, M., S. Rohani, L. Perry, ‘Thermodynamic Modeling and Prediction of Drug Solubility in Solvents: Part 2. The New Model, the UNIQUAC and the NRTL Models', J. Pharmaceutical Sci., 95(4), 798-809 (2006)
• Mirmehrabi, M., S. Rohani, K.S.K. Murthy and B. Radatus, ‘Polymorphic Behaviour and Crystal Habit of an Anti-Viral/HIV Drug: Stavudine', J. Crystal Growth & Des. 6(1), 141-149(2006).
• Mirmehrabi, M., S. Rohani ‘An Approach to Solvent Screening for Crystallization of Polymorphic Pharmaceuticals and Fine Chemicals', J. Pharmaceutical Sci., 94 (7), 1560-1576 (2005).

References