Sodium butyrate
| Sodium butyrate | |
|---|---|
 | |
| IUPAC name Sodium butanoate | |
| Other names Sodium butyrate | |
| Identifiers | |
| CAS number | 156-54-7  |
| PubChem | 5222465 |
| ChemSpider | 8727  |
| ChEMBL | CHEMBL62381 |
| Jmol-3D images | {{#if:CCCC(=O)[O-].[Na+]|Image 1 |
| |
| |
| Properties | |
| Molecular formula | C4H7NaO2 |
| Molar mass | 110.09 g mol−1 |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
| Infobox references | |
Sodium butyrate is a compound with formula Na(C3H7COO). It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expression.[1] As such, it can be used in lab to bring about any of these effects. Specifically, butyrate treatment of cells results in histone hyperacetylation, and butyrate itself inhibits HDAC activity.[2] Butyrate has been an essential vehicle for determining the role of histone acetylation in chromatin structure and function. Inhibition of HDAC activity is estimated to affect the expression of only 2% of mammalian genes.[3]
References
- ↑ Kruh, Jacques (1981). "Effects of sodium butyrate, a new pharmacological agent, on cells in culture". Molecular and Cellular Biochemistry 42 (2): 65–82. doi:10.1007/BF00222695. PMID 6174854.
- ↑ Candido, E; Reeves, Raymond; Davie, James R. (1978). "Sodium butyrate inhibits histone deacetylation in cultured cells". Cell 14 (1): 105–13. doi:10.1016/0092-8674(78)90305-7. PMID 667927.
- ↑ Davie, James R. (2003). "Inhibition of Histone Deacetylase Activity by Butyrate". The Journal of Nutrition 133 (7 Suppl): 2485S–2493S. PMID 12840228.
Further reading
- Govindarajan, Nambirajan; Agis-Balboa, Roberto Carlos; Walter, Jonas; Sananbenesi, Farahnaz; Fischer, André (2011). "Sodium Butyrate Improves Memory Function in an Alzheimer's Disease Mouse Model When Administered at an Advanced Stage of Disease Progression". Journal of Alzheimer's Disease 26 (1): 187–97. doi:10.3233/JAD-2011-110080. PMID 21593570.