Shigekazu Nagata
| Shigekazu Nagata 長田 重一 | |
|---|---|
| Born |
1949 Japan |
| Nationality | Japanese |
| Fields | Molecular biology, biochemistry |
| Institutions |
Kyoto University Osaka University Osaka Bioscience Institute University of Tokyo University of Zurich |
| Alma mater | University of Tokyo |
| Known for |
Apoptosis Interferon Granulocyte colony-stimulating factor Fas ligand Fas receptor |
| Notable awards |
Robert Koch Prize Imperial Prize of the Japan Academy Asahi Prize |
Shigekazu Nagata (長田 重一 Nagata Shigekazu, born 1949) is a Japanese medical researcher, best known for research on apoptosis, the process of programmed cell death occurring in multi-cellular organisms.[1]
Biography
Nagata received his PhD from the Institute of Medical Science, the University of Tokyo in 1977.[2] He served as a postdoctoral fellow at University of Zurich between 1977 and 1981.[2] He was Assistant professor at the Institute of Medical Science, the University of Tokyo between 1982 and 1987, and Head of Department of molecular biology at Osaka Bioscience Institute between 1987 and 1998, and Professor of genetics at Osaka University Medical School between 1995 and 2007, before being appointed as Professor of medical chemistry at the Graduate School of Medicine, Kyoto University in 2007.[2] He was elected a member of the Japan Academy in 2010.
Work
Nagata identified Interferon[3] and Granulocyte colony-stimulating factor.[4]
He also identified a death factor (Fas ligand)[5] and its receptor (Fas receptor),[6] and elucidated their physiological and pathological roles in Apoptosis.[7]
Honors and awards
- 1994: Emil von Boehring Prize, Marburg University (Marburg, Germany)[2]
- 1995: Robert Koch Prize, Koch Foundation (Bonn, Germany)[2]
- 1996: Prix Lacassagne, French Cancer League (Paris, France)[2]
- 1998: Asahi Prize, Asahi Shimbun (Tokyo, Japan)[2]
- 2000: Imperial Prize of the Japan Academy, Japan Academy (Tokyo, Japan)[2]
- 2001: Person of Cultural Merit, Japanese Government (Japan)[2]
- 2004: Cell Death Society Prize, International Cell Death Society (Dublin, Ireland)[2]
- 2012: Honorary Doctorate, University of Zurich (Zurich, Switzerland)[2]
- 2013: Keio Medical Science Prize (with Victor Ambros), Keio University (Tokyo, Japan)[8]
References
- ↑ Cyranoski, D. (2001). "Shigekazu Nagata". Nature Medicine 7 (7): 759. doi:10.1038/89860. PMID 11433328.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 2.10 CV of Shigekazu Nagata, JST (pdf)
- ↑ Nagata, S; Taira, H; Hall, A; Johnsrud, L; Streuli, M; Ecsödi, J; Boll, W; Cantell, K; Weissmann, C (1980). "Synthesis in E. Coli of a polypeptide with human leukocyte interferon activity". Nature 284 (5754): 316–20. PMID 6987533.
- ↑ Nagata, S; Tsuchiya, M; Asano, S; Kaziro, Y; Yamazaki, T; Yamamoto, O; Hirata, Y; Kubota, N; Oheda, M; Nomura, H; Ono, Masayoshi (1986). "Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor". Nature 319 (6052): 415–8. doi:10.1038/319415a0. PMID 3484805.
- ↑ Itoh, N; Yonehara, S; Ishii, A; Yonehara, M; Mizushima, S; Sameshima, M; Hase, A; Seto, Y; Nagata, S (1991). "The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis". Cell 66 (2): 233–43. PMID 1713127.
- ↑ Suda, T; Takahashi, T; Golstein, P; Nagata, S (1993). "Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family". Cell 75 (6): 1169–78. PMID 7505205.
- ↑ "F1000 faculty". Faculty of 1000. Faculty of 1000. Retrieved 28 January 2014.
- ↑ "The 2013 Keio Medical Science Prize Awardees". The Keio Medical Sciences Prize. Keio University. Retrieved 18 January 2014.