Sec61
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| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Pfam | PF00344 | ||||||||
| TCDB | 3.A.5 | ||||||||
| OPM superfamily | 19 | ||||||||
| OPM protein | 2wwb | ||||||||
| |||||||||
Sec61 is an endoplasmic reticulum (ER) membrane protein translocator (aka translocon). It is a doughnut shaped pore through the membrane with 3 major subunits (heterotrimeric). It has a region called the plug that blocks transport into or out of the ER. This plug is displaced when the hydrophobic region of a nascent polypeptide interacts with another region of Sec61 called the seam, allowing translocation of the polypeptide into the ER lumen.
Human proteins
References
- Alberts, Bruce et al. Molecular Biology of the Cell. Garland, 2002. ISBN 0-8153-3218-1
External links
- SEC61 protein at the US National Library of Medicine Medical Subject Headings (MeSH)
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