Schwannoma

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Schwannoma
Classification and external resources

Micrograph of a schwannoma showing both a cellular Antoni A area (center and right of image) and a loose paucicellular Antoni B area (left edge of image). HPS stain.
ICD-10 C72.4
ICD-9 225.1
ICD-O: M9560/0
DiseasesDB 33713
MeSH D009442

A schwannoma (also known as an "neurilemmoma,"[1]:621 "neurinoma,"[2] "neurolemmoma,"[2] and "Schwann cell tumor"[2]) is a benign nerve sheath tumor composed of Schwann cells, which normally produce the insulating myelin sheath covering peripheral nerves.

Schwannomas are very homogeneous tumors, consisting only of Schwann cells. The tumor cells always stay on the outside of the nerve, but the tumor itself may either push the nerve aside and/or up against a bony structure (thereby possibly causing damage). Schwannomas are relatively slow growing. For reasons not yet understood, schwannomas are mostly benign and less than 1% become malignant, degenerating into a form of cancer known as neurofibrosarcoma.

Schwannomas can arise from a genetic disorder called neurofibromatosis. They are universally S-100 positive.

Schwannomas can be removed surgically, but can then recur.

See also

Additional images

  • Schwannoma - Antoni A and B - intermed mag.jpg
  • Peripheral schwannoma Antoni type A (2).JPG

  • Subcutaneous schwannoma

  • Subcutaneous schwannoma (2) Antoni B.jpg
  • Subcutaneous schwannoma (3) Antoni B.jpg
  • Subcutaneous schwannoma (4) S-100 immunostain.jpg

References

  1. ↑ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  2. ↑ 2.0 2.1 2.2 Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 

See also

Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350–9589) (C70–C72, D32–D33, 191–192/225)
Endocrine/
Sellar (9350–9379)
Sellar:
Other:
CNS
(9380–9539)
Neuroepithelial
(brain tumors,
spinal tumors)
Glioma
Astrocyte
Oligodendrocyte
Ependyma
Choroid plexus
Multiple/unknown
Mature
neuron
PNET
Primitive
Meningiomas
(Meninges)
Hematopoietic
PNS: NST
(9540–9579)
Note: Not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain (see brain metastasis).

M: CNS

anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug (N1A/2AB/C/3/4/7A/B/C/D)

M: PNS

anat (h/r/t/c/b/l/s/a)/phys (r)/devp/prot/nttr/nttm/ntrp

noco/auto/cong/tumr, sysi/epon, injr

proc, drug (N1B)

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