Sangamo BioSciences

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Sangamo BioSciences
Type Public
Industry Biomedicine
Founder(s) Edward O. Lanphier II
Headquarters Richmond, California, USA
Employees 84
Website http://www.sangamo.com

Sangamo BioSciences (NASDAQ: SGMO) is a clinical stage biopharmaceutical company involved in gene therapy that is researching ways of commercializing Zinc finger nucleases which modify a cell's DNA at an exact location thereby correcting or disrupting a specific gene.

Sangamo BioSciences' lead therapy, SB-728, is a potential functional cure for HIV/AIDS.[1][2][3] SB-728 works by removing some of the immune cells from the patient's blood that HIV attacks. The blood is sent to a lab which applies the SB-728 treatment to the patient's immune cells. The treatment removes the protein gateway on the immune cells that HIV needs to infect.[4] The treated cells are then infused back into the patient whereby they reproduce and take over as HIV attacks and kills the non-treated cells. The treated, resistant cells thereby control the HIV infection and thus cures the patient from opportunistic infections that result from HIV.[5] Recent published data further support the company's ongoing progress which has been described as "a major step toward immunological functional control of HIV." [6]

References

  1. ↑ "The Man Who Had HIV and Now Does Not". New York Magazine. May 29, 2011. 
  2. ↑ "Sangamo's New Drug To Combat AIDS/HIV Seen As A Potential Game-Changer". Forbes. September 26, 2011. 
  3. ↑ "Pathway to a Cure: Positive Results Continue for Sangamo’s CCR5 Gene Therapy". AIDSMEDS. March 9, 2012. 
  4. ↑ "Sangamo BioSciences Initiates Gene Therapy Trials Toward A Cure For HIV". The AIDS Beacon. January 10, 2012. 
  5. ↑ "Giving HIV a Poor Reception: New AIDS Treatment Tinkers with Immune Cell Genes". Scientific American. March 3, 2011. 
  6. ↑ http://www.prnewswire.com/news-releases/sangamo-biosciences-announces-presentation-of-clinical-data-demonstrating-functional-control-of-viremia-in-hiv-infected-subjects-treated-with-sb-728-t-223525971.html.  Missing or empty |title= (help)

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