Sabeluzole
From Wikipedia, the free encyclopedia
 | |
|---|---|
| Systematic (IUPAC) name | |
| 1-[4-[1,3-benzothiazol-2-yl(methyl)amino]piperidin-1-yl]-3-(4-fluorophenoxy)propan-2-ol | |
| Clinical data | |
| Legal status | Unscheduled |
| Identifiers | |
| CAS number | 104383-17-7 |
| ATC code | None |
| PubChem | CID 59823 |
| ChemSpider | 53964 |
| UNII | A998504XY4  |
| Chemical data | |
| Formula | C22H26FN3O2S |
| Mol. mass | 415.524 g/mol |
| SMILES
| |
| |
| (what is this?) (verify) | |
Sabeluzole (R-58,735) is a nootropic and neuroprotective drug which was originally developed for the treatment of Alzheimer's disease,[1][2] and has subsequently been researched for other applications such as sleep apnoea.[3] It acts primarily as an NMDA antagonist,[4] but other mechanisms of action may also be important.[5][6]
See also
References
- ↑ Clincke GH, Tritsmans L, Idzikowski C, Amery WK, Janssen PA (1988). "The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers". Psychopharmacology 94 (1): 52–7. doi:10.1007/BF00735880. PMID 3126527.
- ↑ Mohr E, Nair NP, Sampson M, Murtha S, Belanger G, Pappas B, Mendis T (August 1997). "Treatment of Alzheimer's disease with sabeluzole: functional and structural correlates". Clinical Neuropharmacology 20 (4): 338–45. PMID 9260731.
- ↑ Hedner J, Grunstein R, Eriksson B, Ejnell H (May 1996). "A double-blind, randomized trial of sabeluzole--a putative glutamate antagonist--in obstructive sleep apnea". Sleep 19 (4): 287–9. PMID 8776785.
- ↑ Van der Valk JB, Vijverberg HP (February 1993). "Chronic sabeluzole treatment of cultured rat cerebellar granule cells reduces N-methyl-D-aspartate-induced inward current". European Journal of Pharmacology 232 (1): 131–4. doi:10.1016/0014-2999(93)90738-4. PMID 8458392.
- ↑ Geerts H, Nuydens R, De Jong M, Cornelissen F, Nuyens R, Wouters L (1996). "Sabeluzole stabilizes the neuronal cytoskeleton". Neurobiology of Aging 17 (4): 573–81. PMID 8832632.
- ↑ Uberti D, Rizzini C, Galli P, Pizzi M, Grilli M, Lesage A, Spano P, Memo M (June 1997). "Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death". Synapse (New York, N.Y.) 26 (2): 95–103. doi:10.1002/(SICI)1098-2396(199706)26:2<95::AID-SYN1>3.0.CO;2-8. PMID 9131769.
| |||||||||||||||||||||||||||||||||||
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.