SYT7
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| Synaptotagmin VII | |||||||||||||
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 PDB rendering based on 2d8k. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SYT7; IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII | ||||||||||||
| External IDs | OMIM: 604146 MGI: 1859545 HomoloGene: 20889 GeneCards: SYT7 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9066 | 54525 | |||||||||||
| Ensembl | ENSG00000011347 | ENSMUSG00000024743 | |||||||||||
| UniProt | O43581 | Q9R0N7 | |||||||||||
| RefSeq (mRNA) | NM_001252065 | NM_018801 | |||||||||||
| RefSeq (protein) | NP_001238994 | NP_061271 | |||||||||||
| Location (UCSC) | Chr 11: 61.28 – 61.35 Mb | Chr 19: 10.39 – 10.45 Mb | |||||||||||
| PubMed search | |||||||||||||
Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.[1][2]
Synaptotagmins, such as SYT7, are brain-specific calcium-dependent phospholipid-binding proteins that play a role in synaptic exocytosis and neurotransmitter release. See MIM 600782.[supplied by OMIM][2]
Interactions
SYT7 has been shown to interact with SYNCRIP.[3]
References
- ↑ Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB (August 1998). "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes". Genomics 49 (3): 419–29. doi:10.1006/geno.1998.5291. PMID 9615227.
- ↑ 2.0 2.1 "Entrez Gene: SYT7 synaptotagmin VII".
- ↑ Mizutani, A; Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. (UNITED STATES) 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. ISSN 0021-9258. PMID 10734137.
Further reading
- Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.". Nature 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin.". Biochemistry 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
- Craxton M, Goedert M (1999). "Alternative splicing of synaptotagmins involving transmembrane exon skipping.". FEBS Lett. 460 (3): 417–22. doi:10.1016/S0014-5793(99)01382-4. PMID 10556508.
- Walker MG, Volkmuth W, Sprinzak E, et al. (2000). "Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes.". Genome Res. 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC 310991. PMID 10613842.
- Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
- Caler EV, Chakrabarti S, Fowler KT, et al. (2001). "The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi.". J. Exp. Med. 193 (9): 1097–104. doi:10.1084/jem.193.9.1097. PMC 2193425. PMID 11342594.
- Fukuda M, Ogata Y, Saegusa C, et al. (2002). "Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human.". Biochem. J. 365 (Pt 1): 173–80. doi:10.1042/BJ20011877. PMC 1222667. PMID 12071850.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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