SYT2
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| Synaptotagmin II | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SYT2; SytII | ||||||||||||
| External IDs | OMIM: 600104 MGI: 99666 HomoloGene: 22516 GeneCards: SYT2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 127833 | 20980 | |||||||||||
| Ensembl | ENSG00000143858 | ENSMUSG00000026452 | |||||||||||
| UniProt | Q8N9I0 | P46097 | |||||||||||
| RefSeq (mRNA) | NM_001136504 | NM_009307 | |||||||||||
| RefSeq (protein) | NP_001129976 | NP_033333 | |||||||||||
| Location (UCSC) | Chr 1: 202.56 – 202.68 Mb | Chr 1: 134.71 – 134.75 Mb | |||||||||||
| PubMed search | |||||||||||||
Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene.[1][2]
References
- ↑ Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (Jun 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mamm Genome 6 (3): 212–3. doi:10.1007/BF00293017. PMID 7749232.
- ↑ "Entrez Gene: SYT2 synaptotagmin II".
Further reading
- Fukuda M, Aruga J, Niinobe M et al. (1994). "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II". J. Biol. Chem. 269 (46): 29206–11. PMID 7961887.
- Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
- Baram D, Adachi R, Medalia O et al. (1999). "Synaptotagmin II Negatively Regulates Ca2+-triggered Exocytosis of Lysosomes in Mast Cells". J. Exp. Med. 189 (10): 1649–58. doi:10.1084/jem.189.10.1649. PMC 2193646. PMID 10330444.
- Mizutani A, Fukuda M, Ibata K et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
- Kida Y, Sakaguchi M, Fukuda M et al. (2000). "Membrane Topogenesis of a Type I Signal-Anchor Protein, Mouse Synaptotagmin Ii, on the Endoplasmic Reticulum". J. Cell Biol. 150 (4): 719–30. doi:10.1083/jcb.150.4.719. PMC 2175286. PMID 10952998.
- Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (2001). "Stonin 2: An Adaptor-like Protein That Interacts with Components of the Endocytic Machinery". J. Cell Biol. 153 (5): 1111–20. doi:10.1083/jcb.153.5.1111. PMC 2174325. PMID 11381094.
- Kida Y, Sakaguchi M, Fukuda M et al. (2001). "Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II". FEBS Lett. 507 (3): 341–5. doi:10.1016/S0014-5793(01)03000-9. PMID 11696368.
- Lindmark IM, Karlsson A, Serrander L et al. (2002). "Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils". Biochim. Biophys. Acta 1590 (1–3): 159–66. doi:10.1016/S0167-4889(02)00209-4. PMID 12063179.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Rickman C, Archer DA, Meunier FA et al. (2004). "Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate". J. Biol. Chem. 279 (13): 12574–9. doi:10.1074/jbc.M310710200. PMID 14709554.
- Lee BH, Min X, Heise CJ et al. (2004). "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding". Mol. Cell 15 (5): 741–51. doi:10.1016/j.molcel.2004.07.018. PMID 15350218.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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