SUV39H2

From Wikipedia, the free encyclopedia

Suppressor of variegation 3-9 homolog 2 (Drosophila)

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2R3A

Identifiers

SUV39H2; KMT1B

External IDs

OMIM: 606503 MGI: 1890396 HomoloGene: 32548 ChEMBL: 1795177 GeneCards: SUV39H2 Gene

Gene Ontology
Molecular function	• chromatin binding • protein binding • zinc ion binding • histone methyltransferase activity (H3-K9 specific)
Cellular component	• chromosome, centromeric region • chromatin • nuclear heterochromatin
Biological process	• chromatin assembly or disassembly • chromatin remodeling • transcription, DNA-dependent • regulation of transcription, DNA-dependent • male meiosis • cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000152455

ENSMUSG00000026646

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
14.92 – 14.95 Mb

Chr 2:
3.46 – 3.48 Mb

PubMed search

Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene.^[1]^[2]

References

↑ O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T (Dec 2000). "Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression". Mol Cell Biol 20 (24): 9423–33. doi:10.1128/MCB.20.24.9423-9433.2000. PMC 102198. PMID 11094092.
↑ "Entrez Gene: SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Rea S, Eisenhaber F, O'Carroll D, et al. (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature 406 (6796): 593–9. doi:10.1038/35020506. PMID 10949293.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ait-Si-Ali S, Guasconi V, Fritsch L, et al. (2005). "A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells". EMBO J. 23 (3): 605–15. doi:10.1038/sj.emboj.7600074. PMC 1271807. PMID 14765126.
Frontelo P, Leader JE, Yoo N, et al. (2004). "Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression". Oncogene 23 (30): 5242–51. doi:10.1038/sj.onc.1207660. PMID 15107829.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Yoon KA, Hwangbo B, Kim IJ, et al. (2006). "Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer". Carcinogenesis 27 (11): 2217–22. doi:10.1093/carcin/bgl084. PMID 16774942.

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