SUV39H1

From Wikipedia, the free encyclopedia
Suppressor of variegation 3-9 homolog 1 (Drosophila)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsSUV39H1; KMT1A; MG44; SUV39H
External IDsOMIM: 300254 MGI: 1099440 HomoloGene: 2388 ChEMBL: 1795118 GeneCards: SUV39H1 Gene
EC number2.1.1.43
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez683920937
EnsemblENSG00000101945ENSMUSG00000039231
UniProtO43463O54864
RefSeq (mRNA)NM_003173NM_011514
RefSeq (protein)NP_003164NP_035644
Location (UCSC)Chr HG1436_HG1432_PATCH:
48.55 – 48.57 Mb
Chr X:
8.06 – 8.07 Mb
PubMed search

Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.[1]

This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.[2]

Interactions

SUV39H1 has been shown to interact with HDAC9,[3] HDAC1,[4] Histone deacetylase 2,[4] Retinoblastoma protein,[5][6] CBX5,[3][7][8] HDAC3,[4] DNMT3A,[9] MBD1,[7] RUNX1,[10] SBF1[11] and CBX1.[1]

References

  1. 1.0 1.1 Aagaard L, Laible G, Selenko P, Schmid M, Dorn R, Schotta G, Kuhfittig S, Wolf A, Lebersorger A, Singh PB, Reuter G, Jenuwein T (June 1999). "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31". EMBO J 18 (7): 1923–38. doi:10.1093/emboj/18.7.1923. PMC 1171278. PMID 10202156. 
  2. "Entrez Gene: SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)". 
  3. 3.0 3.1 Zhang, Chun Li; McKinsey Timothy A, Olson Eric N (October 2002). "Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation". Mol. Cell. Biol. (United States) 22 (20): 7302–12. doi:10.1128/MCB.22.20.7302-7312.2002. ISSN 0270-7306. PMC 139799. PMID 12242305. 
  4. 4.0 4.1 4.2 Vaute, Olivier; Nicolas Estelle, Vandel Laurence, Trouche Didier (January 2002). "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases". Nucleic Acids Res. (England) 30 (2): 475–81. doi:10.1093/nar/30.2.475. PMC 99834. PMID 11788710. 
  5. Nielsen, S J; Schneider R, Bauer U M, Bannister A J, Morrison A, O'Carroll D, Firestein R, Cleary M, Jenuwein T, Herrera R E, Kouzarides T (August 2001). "Rb targets histone H3 methylation and HP1 to promoters". Nature (England) 412 (6846): 561–5. doi:10.1038/35087620. ISSN 0028-0836. PMID 11484059. 
  6. Vandel, L; Nicolas E, Vaute O, Ferreira R, Ait-Si-Ali S, Trouche D (October 2001). "Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase". Mol. Cell. Biol. (United States) 21 (19): 6484–94. doi:10.1128/MCB.21.19.6484-6494.2001. ISSN 0270-7306. PMC 99795. PMID 11533237. 
  7. 7.0 7.1 Fujita, Naoyuki; Watanabe Sugiko, Ichimura Takaya, Tsuruzoe Shu, Shinkai Yoichi, Tachibana Makoto, Chiba Tsutomu, Nakao Mitsuyoshi (June 2003). "Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression". J. Biol. Chem. (United States) 278 (26): 24132–8. doi:10.1074/jbc.M302283200. ISSN 0021-9258. PMID 12711603. 
  8. Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  9. Fuks, François; Hurd Paul J, Deplus Rachel, Kouzarides Tony (May 2003). "The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase". Nucleic Acids Res. (England) 31 (9): 2305–12. doi:10.1093/nar/gkg332. PMC 154218. PMID 12711675. 
  10. Chakraborty, Soumen; Sinha Kislay Kumar, Senyuk Vitalyi, Nucifora Giuseppina (August 2003). "SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo". Oncogene (England) 22 (34): 5229–37. doi:10.1038/sj.onc.1206600. ISSN 0950-9232. PMID 12917624. 
  11. Firestein, R; Cui X, Huie P, Cleary M L (July 2000). "Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4900–9. doi:10.1128/MCB.20.13.4900-4909.2000. ISSN 0270-7306. PMC 85941. PMID 10848615. 

Further reading


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