STXBP5
From Wikipedia, the free encyclopedia
| Syntaxin binding protein 5 (tomosyn) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB rendering based on 1urq. | |||||||||||||
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | STXBP5; LGL3; LLGL3; Nbla04300 | ||||||||||||
| External IDs | OMIM: 604586 MGI: 1926058 HomoloGene: 16402 GeneCards: STXBP5 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 134957 | 78808 | |||||||||||
| Ensembl | ENSG00000164506 | ENSMUSG00000019790 | |||||||||||
| UniProt | Q5T5C0 | D3Z079 | |||||||||||
| RefSeq (mRNA) | NM_001127715 | NM_001081344 | |||||||||||
| RefSeq (protein) | NP_001121187 | NP_001074813 | |||||||||||
| Location (UCSC) | Chr 6: 147.53 – 147.71 Mb | Chr 10: 9.76 – 9.9 Mb | |||||||||||
| PubMed search | |||||||||||||
Syntaxin-binding protein 5 is a protein that in humans is encoded by the STXBP5 gene.[1][2][3]
Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced variants have been identified, but their biological validity has not been determined.[3]
Interactions
STXBP5 has been shown to interact with STX4[4] and STX1A.[1][4]
References
- ↑ 1.0 1.1 Fujita Y, Shirataki H, Sakisaka T, Asakura T, Ohya T, Kotani H, Yokoyama S, Nishioka H, Matsuura Y, Mizoguchi A, Scheller RH, Takai Y (Jun 1998). "Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process". Neuron 20 (5): 905–15. doi:10.1016/S0896-6273(00)80472-9. PMID 9620695.
- ↑ Katoh M, Katoh M (Feb 2004). "Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico". Int J Oncol 24 (3): 737–42. PMID 14767561.
- ↑ 3.0 3.1 "Entrez Gene: STXBP5 syntaxin binding protein 5 (tomosyn)".
- ↑ 4.0 4.1 Widberg, Charlotte H; Bryant Nia J, Girotti Milena, Rea Shane, James David E (Sep 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. (United States) 278 (37): 35093–101. doi:10.1074/jbc.M304261200. ISSN 0021-9258. PMID 12832401.
Further reading
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Widberg CH, Bryant NJ, Girotti M, et al. (2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation.". J. Biol. Chem. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yokoyama S, Shirataki H, Sakisaka T, Takai Y (1999). "Three splicing variants of tomosyn and identification of their syntaxin-binding region.". Biochem. Biophys. Res. Commun. 256 (1): 218–22. doi:10.1006/bbrc.1999.0300. PMID 10066450.
| ||||||||
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.