STX6
From Wikipedia, the free encyclopedia
| Syntaxin 6 | |||||||||||||
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 PDB rendering based on 1lvf. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbol | STX6 | ||||||||||||
| External IDs | OMIM: 603944 MGI: 1926235 HomoloGene: 115622 GeneCards: STX6 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10228 | 58244 | |||||||||||
| Ensembl | ENSG00000135823 | ENSMUSG00000026470 | |||||||||||
| UniProt | O43752 | Q9JKK1 | |||||||||||
| RefSeq (mRNA) | NM_005819 | NM_021433 | |||||||||||
| RefSeq (protein) | NP_005810 | NP_067408 | |||||||||||
| Location (UCSC) | Chr 1: 180.94 – 180.99 Mb | Chr 1: 155.16 – 155.2 Mb | |||||||||||
| PubMed search | |||||||||||||
Syntaxin-6 is a protein that in humans is encoded by the STX6 gene.[1][2]
Interactions
STX6 has been shown to interact with SNAP23,[3] VAMP3[4] and VAMP4.[4]
References
- ↑ Martin-Martin B, Nabokina SM, Lazo PA, Mollinedo F (April 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J Leukoc Biol 65 (3): 397–406. PMID 10080545.
- ↑ "Entrez Gene: STX6 syntaxin 6".
- ↑ Martín-Martín, B; Nabokina S M, Blasi J, Lazo P A, Mollinedo F (October 2000). "Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis". Blood (UNITED STATES) 96 (7): 2574–83. ISSN 0006-4971. PMID 11001914.
- ↑ 4.0 4.1 Mallard, Frédéric; Tang Bor Luen, Galli Thierry, Tenza Danièle, Saint-Pol Agnès, Yue Xu, Antony Claude, Hong Wanjin, Goud Bruno, Johannes Ludger (February 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. (United States) 156 (4): 653–64. doi:10.1083/jcb.200110081. ISSN 0021-9525. PMC 2174079. PMID 11839770.
Further reading
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Bock JB, Lin RC, Scheller RH (1996). "A new syntaxin family member implicated in targeting of intracellular transport vesicles.". J. Biol. Chem. 271 (30): 17961–5. doi:10.1074/jbc.271.30.17961. PMID 8663448.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Simonsen A, Lippé R, Christoforidis S, et al. (1998). "EEA1 links PI(3)K function to Rab5 regulation of endosome fusion.". Nature 394 (6692): 494–8. doi:10.1038/28879. PMID 9697774.
- Wong SH, Xu Y, Zhang T, et al. (1999). "GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6.". Mol. Biol. Cell 10 (1): 119–34. PMC 25158. PMID 9880331.
- Steegmaier M, Klumperman J, Foletti DL, et al. (1999). "Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking.". Mol. Biol. Cell 10 (6): 1957–72. PMC 25394. PMID 10359608.
- Simonsen A, Gaullier JM, D'Arrigo A, Stenmark H (1999). "The Rab5 effector EEA1 interacts directly with syntaxin-6.". J. Biol. Chem. 274 (41): 28857–60. doi:10.1074/jbc.274.41.28857. PMID 10506127.
- Scales SJ, Chen YA, Yoo BY, et al. (2000). "SNAREs contribute to the specificity of membrane fusion.". Neuron 26 (2): 457–64. doi:10.1016/S0896-6273(00)81177-0. PMID 10839363.
- Martín-Martín B, Nabokina SM, Blasi J, et al. (2000). "Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis.". Blood 96 (7): 2574–83. PMID 11001914.
- Wade N, Bryant NJ, Connolly LM, et al. (2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells.". J. Biol. Chem. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.
- Charest A, Lane K, McMahon K, Housman DE (2001). "Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6.". J. Biol. Chem. 276 (31): 29456–65. doi:10.1074/jbc.M104137200. PMID 11384996.
- Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.". J. Biol. Chem. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. PMID 11423532.
- Cheng J, Moyer BD, Milewski M, et al. (2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression.". J. Biol. Chem. 277 (5): 3520–9. doi:10.1074/jbc.M110177200. PMID 11707463.
- Mallard F, Tang BL, Galli T, et al. (2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform.". J. Cell Biol. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Martinez-Arca S, Rudge R, Vacca M, et al. (2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs.". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575.
- Kim BY, Ueda M, Kominami E, et al. (2004). "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex.". Biochem. Biophys. Res. Commun. 311 (3): 577–82. doi:10.1016/j.bbrc.2003.10.030. PMID 14623309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Huynh H, Bottini N, Williams S, et al. (2004). "Control of vesicle fusion by a tyrosine phosphatase.". Nat. Cell Biol. 6 (9): 831–9. doi:10.1038/ncb1164. PMID 15322554.
External links
- STX6 human gene location in the UCSC Genome Browser.
- STX6 human gene details in the UCSC Genome Browser.
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