STX2
From Wikipedia, the free encyclopedia
| Syntaxin 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | STX2; EPIM; EPM; STX2A; STX2B; STX2C | ||||||||||||
| External IDs | OMIM: 132350 MGI: 108059 HomoloGene: 37559 GeneCards: STX2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2054 | 13852 | |||||||||||
| Ensembl | ENSG00000111450 | ENSMUSG00000029428 | |||||||||||
| UniProt | P32856 | D3YY94 | |||||||||||
| RefSeq (mRNA) | NM_001980 | NM_007941 | |||||||||||
| RefSeq (protein) | NP_001971 | NP_031967 | |||||||||||
| Location (UCSC) | Chr 12: 131.27 – 131.32 Mb | Chr 5: 128.98 – 129.01 Mb | |||||||||||
| PubMed search | |||||||||||||
Syntaxin-2 is a protein that in humans is encoded by the STX2 gene.[1][2][3]
The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
Interactions
STX2 has been shown to interact with SNAP-25,[4][5] SNAP23,[5][6][7][8] STXBP1[4][9] and Syntaxin binding protein 3.[9]
References
- ↑ Zha H, Remmers EF, Szpirer C, Szpirer J, Zhang H, Kozak CA, Wilder RL (Mar 1997). "The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12". Genomics 37 (3): 386–9. doi:10.1006/geno.1996.0574. PMID 8938452.
- ↑ Band AM, Kuismanen E (Jun 2005). "Localization of plasma membrane t-SNAREs syntaxin 2 and 3 in intracellular compartments". BMC Cell Biol 6: 26. doi:10.1186/1471-2121-6-26. PMC 1156879. PMID 15943887.
- ↑ 3.0 3.1 "Entrez Gene: STX2 syntaxin 2".
- ↑ 4.0 4.1 Hata, Y; Südhof T C (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. (UNITED STATES) 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. ISSN 0021-9258. PMID 7768895.
- ↑ 5.0 5.1 Ravichandran, V; Chawla A, Roche P A (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. (UNITED STATES) 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. ISSN 0021-9258. PMID 8663154.
- ↑ Imai, Akane; Nashida Tomoko, Yoshie Sumio, Shimomura Hiromi (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. (England) 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. ISSN 0003-9969. PMID 12828989.
- ↑ Li, Guangmu; Alexander Edward A, Schwartz John H (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". J. Biol. Chem. (United States) 278 (22): 19791–7. doi:10.1074/jbc.M212250200. ISSN 0021-9258. PMID 12651853.
- ↑ Araki, S; Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. (UNITED STATES) 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. ISSN 0006-291X. PMID 9168999.
- ↑ 9.0 9.1 Schraw, Todd D; Lemons Paula P, Dean William L, Whiteheart Sidney W (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. (England) 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. ISSN 0264-6021. PMC 1223584. PMID 12773094.
Further reading
- Hirai Y, Takebe K, Takashina M, et al. (1992). "Epimorphin: a mesenchymal protein essential for epithelial morphogenesis". Cell 69 (3): 471–81. doi:10.1016/0092-8674(92)90448-L. PMID 1581962.
- Hata Y, Südhof TC (1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
- Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.
- Hirai Y (1993). "Molecular cloning of human epimorphin: identification of isoforms and their unique properties". Biochem. Biophys. Res. Commun. 191 (3): 1332–7. doi:10.1006/bbrc.1993.1363. PMID 8466509.
- Oka Y, Hirai Y (1996). "Inductive influences of epimorphin on endothelial cells in vitro". Exp. Cell Res. 222 (1): 189–98. doi:10.1006/excr.1996.0024. PMID 8549663.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Betz A, Okamoto M, Benseler F, Brose N (1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". J. Biol. Chem. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.
- Tellam JT, Macaulay SL, McIntosh S, et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". J. Biol. Chem. 272 (10): 6179–86. doi:10.1074/jbc.272.10.6179. PMID 9045631.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Koshida S, Hirai Y (1997). "Identification of cellular recognition sequence of epimorphin and critical role of cell/epimorphin interaction in lung branching morphogenesis". Biochem. Biophys. Res. Commun. 234 (2): 522–5. doi:10.1006/bbrc.1997.6673. PMID 9177305.
- Hirai Y, Lochter A, Galosy S, et al. (1998). "Epimorphin Functions as a Key Morphoregulator for Mammary Epithelial Cells". J. Cell Biol. 140 (1): 159–69. doi:10.1083/jcb.140.1.159. PMC 2132590. PMID 9425164.
- Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and Biochemical Analysis of the C2 Domains of Synaptotagmin IV". Mol. Biol. Cell 10 (7): 2285–95. PMC 25443. PMID 10397765.
- Pabst S, Hazzard JW, Antonin W, et al. (2000). "Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions". J. Biol. Chem. 275 (26): 19808–18. doi:10.1074/jbc.M002571200. PMID 10777504.
- Kauppi M, Wohlfahrt G, Olkkonen VM (2003). "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3". J. Biol. Chem. 277 (46): 43973–9. doi:10.1074/jbc.M208315200. PMID 12198139.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Terasaki Y, Fukuda Y, Suga M, et al. (2006). "Epimorphin expression in interstitial pneumonia". Respir. Res. 6 (1): 6. doi:10.1186/1465-9921-6-6. PMC 548284. PMID 15651999.
- Low SH, Vasanji A, Nanduri J, et al. (2006). "Syntaxins 3 and 4 Are Concentrated in Separate Clusters on the Plasma Membrane before the Establishment of Cell Polarity". Mol. Biol. Cell 17 (2): 977–89. doi:10.1091/mbc.E05-05-0462. PMC 1356605. PMID 16339081.
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