STX11
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| Syntaxin 11 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | STX11; FHL4; HLH4; HPLH4 | ||||||||||||
| External IDs | OMIM: 605014 MGI: 1921982 HomoloGene: 2792 GeneCards: STX11 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8676 | 74732 | |||||||||||
| Ensembl | ENSG00000135604 | ENSMUSG00000039232 | |||||||||||
| UniProt | O75558 | Q9D3G5 | |||||||||||
| RefSeq (mRNA) | NM_003764 | NM_001163590 | |||||||||||
| RefSeq (protein) | NP_003755 | NP_001157062 | |||||||||||
| Location (UCSC) | Chr 6: 144.47 – 144.51 Mb | Chr 10: 12.94 – 12.96 Mb | |||||||||||
| PubMed search | |||||||||||||
Syntaxin 11, also known as STX11, is a human gene that is a member of the t-SNARE family.[1]
Interactions
STX11 has been shown to interact with SNAP-25[2][3] and SNAP23.[2][4]
See also
References
- ↑ "Entrez Gene: STX11 syntaxin 11".
- ↑ 2.0 2.1 Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ↑ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070.
- ↑ Valdez, A C; Cabaniols J P, Brown M J, Roche P A (Mar 1999). "Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network". J. Cell. Sci. (ENGLAND) 112 (6): 845–54. ISSN 0021-9533. PMID 10036234.
Further reading
- Advani RJ, Bae HR, Bock JB et al. (1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". J. Biol. Chem. 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086.
- Tang BL, Low DY, Hong W (1998). "Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain". Biochem. Biophys. Res. Commun. 245 (2): 627–32. doi:10.1006/bbrc.1998.8490. PMID 9571206.
- Valdez AC, Cabaniols JP, Brown MJ, Roche PA (1999). "Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network". J. Cell. Sci. 112 (6): 845–54. PMID 10036234.
- Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol. 65 (3): 397–406. PMID 10080545.
- Roperch JP, Lethrone F, Prieur S et al. (1999). "SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: Identification of common effectors with p53 and p21Waf1". Proc. Natl. Acad. Sci. U.S.A. 96 (14): 8070–3. doi:10.1073/pnas.96.14.8070. PMC 22189. PMID 10393949.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- zur Stadt U, Schmidt S, Kasper B et al. (2005). "Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11". Hum. Mol. Genet. 14 (6): 827–34. doi:10.1093/hmg/ddi076. PMID 15703195.
- Stelzl U, Worm U, Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Yamamoto K, Ishii E, Horiuchi H et al. (2006). "Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people". J. Hum. Genet. 50 (11): 600–3. doi:10.1007/s10038-005-0293-1. PMID 16180048.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Zur Stadt U, Beutel K, Kolberg S et al. (2006). "Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A". Hum. Mutat. 27 (1): 62–8. doi:10.1002/humu.20274. PMID 16278825.
- Bryceson YT, Rudd E, Zheng C et al. (2007). "Defective cytotoxic lymphocyte degranulation in syntaxin-11–deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients". Blood 110 (6): 1906–15. doi:10.1182/blood-2007-02-074468. PMC 1976360. PMID 17525286.
- Arneson LN, Brickshawana A, Segovis CM et al. (2007). "Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity". J. Immunol. 179 (6): 3397–401. PMID 17785771.
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