SOX13
From Wikipedia, the free encyclopedia
| SRY (sex determining region Y)-box 13 | |||||||||||||
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 PDB rendering based on 1i11. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SOX13; ICA12; Sox-13 | ||||||||||||
| External IDs | OMIM: 604748 MGI: 98361 HomoloGene: 4159 GeneCards: SOX13 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9580 | 20668 | |||||||||||
| Ensembl | ENSG00000143842 | ENSMUSG00000070643 | |||||||||||
| UniProt | Q9UN79 | Q04891 | |||||||||||
| RefSeq (mRNA) | NM_005686 | NM_011439 | |||||||||||
| RefSeq (protein) | NP_005677 | NP_035569 | |||||||||||
| Location (UCSC) | Chr 1: 204.04 – 204.1 Mb | Chr 1: 133.38 – 133.42 Mb | |||||||||||
| PubMed search | |||||||||||||
Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.[1][2]
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.[2]
In melanocytic cells SOX13 gene expression may be regulated by MITF.[3]
See also
- SOX genes
References
- ↑ Roose J, Korver W, de Boer R, Kuipers J, Hurenkamp J, Clevers H (May 1999). "The Sox-13 gene: structure, promoter characterization, and chromosomal localization". Genomics 57 (2): 301–5. doi:10.1006/geno.1999.5779. PMID 10198172.
- ↑ 2.0 2.1 "Entrez Gene: SOX13 SRY (sex determining region Y)-box 13".
- ↑ Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
Further reading
- Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
- Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Dev. Cell 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
- Roose J, Korver W, Oving E et al. (1998). "High expression of the HMG box factor sox-13 in arterial walls during embryonic development". Nucleic Acids Res. 26 (2): 469–76. doi:10.1093/nar/26.2.469. PMC 147262. PMID 9421502.
- Argentaro A, Olsson J, Critcher R et al. (2000). "Genomic characterisation and fine mapping of the human SOX13 gene". Gene 250 (1–2): 181–9. doi:10.1016/S0378-1119(00)00157-8. PMID 10854791.
- Kasimiotis H, Myers MA, Argentaro A et al. (2000). "Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets". Diabetes 49 (4): 555–61. doi:10.2337/diabetes.49.4.555. PMID 10871192.
- Steinbrenner H, Lohmann T, Ostendorf B et al. (2001). "Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes". Diabetologia 43 (11): 1381–4. doi:10.1007/s001250051542. PMID 11126406.
- Kasimiotis H, Fida S, Rowley MJ et al. (2001). "Antibodies to SOX13 (ICA12) are associated with type 1 diabetes". Autoimmunity 33 (2): 95–101. doi:10.3109/08916930108995994. PMID 11264788.
- Lampasona V, Scirpoli M, Bosi E, Bonifacio E (2001). "ICA12(SOX13) autoantibodies are unlikely to be a useful marker for pre-clinical Type I diabetes". Diabetologia 44 (2): 267–267. doi:10.1007/s001250051610. PMID 11270687.
- Argentaro A, Wapelhorst B, Concannon P, Harley VR (2001). "Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes". Mol. Genet. Metab. 72 (4): 356–9. doi:10.1006/mgme.2000.3136. PMID 11286511.
- Fida S, Myers M, Mackay IR et al. (2001). "Antibodies to diabetes-associated autoantigens in Indian patients with Type 1 diabetes: prevalence of anti-ICA512/IA2 and anti-SOX13". Diabetes Res. Clin. Pract. 52 (3): 205–11. doi:10.1016/S0168-8227(01)00230-3. PMID 11323090.
- Tandon N, Shtauvere-Brameus A, Hagopian WA, Sanjeevi CB (2002). "Prevalence of ICA-12 and other autoantibodies in north Indian patients with early-onset diabetes". Ann. N. Y. Acad. Sci. 958: 214–7. doi:10.1111/j.1749-6632.2002.tb02972.x. PMID 12021109.
- Törn C, Shtauvere-Brameus A, Sanjeevi CB, Landin-Olsson M (2002). "Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes". Ann. N. Y. Acad. Sci. 958: 218–23. doi:10.1111/j.1749-6632.2002.tb02973.x. PMID 12021110.
- Shtauvere-Brameus A, Hagopian W, Rumba I, Sanjeevi CB (2002). "Antibodies to new beta cell antigen ICA12 in Latvian diabetes patients". Ann. N. Y. Acad. Sci. 958: 297–304. doi:10.1111/j.1749-6632.2002.tb02991.x. PMID 12021128.
- Gupta M, Tandon N, Shtauvere-Brameus A, Sanjeevi CB (2002). "ICA12 autoantibodies are associated with non-DR3/non-DR4 in patients with latent autoimmune diabetes in adults from northern India". Ann. N. Y. Acad. Sci. 958: 329–32. doi:10.1111/j.1749-6632.2002.tb02998.x. PMID 12021135.
- Fida S, Myers MA, Whittingham S et al. (2003). "Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases". J. Autoimmun. 19 (4): 251–7. doi:10.1006/jaut.2002.0622. PMID 12473246.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Park Y, Park H, Yoo E, Kim D (2004). "SOX13 autoantibodies are likely to be a supplementary marker for type 1 diabetes in Korea". Ann. N. Y. Acad. Sci. 1005: 253–8. doi:10.1196/annals.1288.038. PMID 14679071.
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External links
- SOX13 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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