SOX11

From Wikipedia, the free encyclopedia

SRY (sex determining region Y)-box 11

Identifiers

External IDs

OMIM: 600898 MGI: 98359 HomoloGene: 37733 GeneCards: SOX11 Gene

Gene Ontology
Molecular function	• transcription regulatory region sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • nucleic acid binding transcription factor activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • RNA polymerase II transcription coactivator activity • enhancer sequence-specific DNA binding • translation factor activity, nucleic acid binding
Cellular component	• nucleus • cytoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • skeletal system development • kidney development • neural tube formation • lens morphogenesis in camera-type eye • outflow tract morphogenesis • cardiac ventricle formation • noradrenergic neuron differentiation • translation • positive regulation of cell proliferation • positive regulation of gene expression • negative regulation of gene expression • oligodendrocyte development • glial cell proliferation • neural crest cell development • regulation of transforming growth factor beta receptor signaling pathway • spinal cord development • glial cell development • neuron differentiation • positive regulation of BMP signaling pathway • positive regulation of hippo signaling cascade • positive regulation of neuron differentiation • positive regulation of osteoblast differentiation • positive regulation of ossification • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of hormone secretion • sympathetic nervous system development • embryonic digestive tract morphogenesis • embryonic skeletal system morphogenesis • negative regulation of lymphocyte proliferation • positive regulation of neurogenesis • hard palate development • soft palate development • limb bud formation • negative regulation of glial cell proliferation • ventricular septum morphogenesis • lung morphogenesis • negative regulation of cell death • neuroepithelial cell differentiation • eyelid development in camera-type eye • somite development • cornea development in camera-type eye • closure of optic fissure • signal transduction involved in cell cycle checkpoint • positive regulation of stem cell proliferation • negative regulation of transcription regulatory region DNA binding • positive regulation of lens epithelial cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
5.83 – 5.84 Mb

Chr 12:
27.34 – 27.34 Mb

PubMed search

Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.^[1]^[2]^[3]

This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis.^[3]^[4] Tuj1 and Tead2 are suggested as direct target of Sox11.^[5]^[6]^[7]

References

↑ Jay P, Goze C, Marsollier C, Taviaux S, Hardelin JP, Koopman P, Berta P (Aug 1996). "The human SOX11 gene: cloning, chromosomal assignment and tissue expression". Genomics 29 (2): 541–5. doi:10.1006/geno.1995.9970. PMID 8666406.
↑ Wiebe MS, Nowling TK, Rizzino A (May 2003). "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity". J Biol Chem 278 (20): 17901–11. doi:10.1074/jbc.M212211200. PMID 12637543.
↑ 3.0 3.1 "Entrez Gene: SOX11 SRY (sex determining region Y)-box 11".
↑ Haslinger A, Schwarz TJ, Covic M, Chichung Lie D. (May 2009). "Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis". Eur J Neurosci. 29 (11): 2103–14. doi:10.1111/j.1460-9568.2009.06768.x. PMID 19490090.
↑ Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J. (Dec 2006). "The establishment of neuronal properties is controlled by Sox4 and Sox11". Genes Dev. 20 (24): 3475–86. doi:10.1101/gad.403406. PMC 1698453. PMID 17182872.
↑ Bhattaram P, Penzo-Méndez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V. (Apr 2010). "Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors". Nat Commun. 1 (1): 9. doi:10.1038/ncomms1008. PMC 2892298. PMID 20596238.
↑ Larson, Benjamin; Ylostalo, Joni; Lee, Ryang H; Gregory, Carl; Prockop, Darwin J (November 2010). "Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells.". Tissue Eng Part A 11 (11): 3385–94. doi:10.1089/ten.tea.2010.0085. PMC 2965191. PMID 20626275. Cite uses deprecated parameters (help)

Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Dev. Cell 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Res. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMC 309692. PMID 8332506.
Kuhlbrodt K, Herbarth B, Sock E et al. (1998). "Cooperative function of POU proteins and SOX proteins in glial cells". J. Biol. Chem. 273 (26): 16050–7. doi:10.1074/jbc.273.26.16050. PMID 9632656.
Azuma T, Ao S, Saito Y et al. (2000). "Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region". DNA Res. 6 (5): 357–60. doi:10.1093/dnares/6.5.357. PMID 10574465.
Lee CJ, Appleby VJ, Orme AT et al. (2003). "Differential expression of SOX4 and SOX11 in medulloblastoma". J. Neurooncol. 57 (3): 201–14. doi:10.1023/A:1015773818302. PMID 12125983.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ballif BA, Villén J, Beausoleil SA et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Bouma GJ, Albrecht KH, Washburn LL et al. (2005). "Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells". Development 132 (13): 3045–54. doi:10.1242/dev.01890. PMID 15944188.
Thevenet L, Albrecht KH, Malki S et al. (2006). "NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY". J. Biol. Chem. 280 (46): 38625–30. doi:10.1074/jbc.M504127200. PMID 16166090.
DesGroseilliers M, Fortin F, Lemyre E, Lemieux N (2006). "Complex mosaicism in sex reversed SRY+ male twins". Cytogenet. Genome Res. 112 (1–2): 176–9. doi:10.1159/000087532. PMID 16276109.

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 (c-Fos, FOSB, FOSL1, FOSL2, JDP2, c-Jun, JUNB, JUND) · BACH (1, 2) · BATF · BLZF1 · C/EBP (α, β, γ, δ, ε, ζ) · CREB (1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF (B, F, G, K) · NFE (2, L1, L2, L3) · NFIL3 · NRL · NRF (1, 2, 3) · XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLH (2, 3, 9) · BMAL (ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND (1, 2) · HES (5, 6) · HEY (1, 2, L) · HES1 · HIF (1A, 3A) · ID (1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) · Neurogenins (1, 2, 3) · NeuroD (1, 2) · NPAS (1, 2, 3) · OLIG (1, 2) · Pho4 · Scleraxis · SIM (1, 2) · TAL (1, 2) · Twist · USF1

(1.3) bHLH-ZIP	AP-4 · MAX (MXD3) · MITF · MNT · MLX · MXI1 · Myc · SREBP (1, 2)

(1.4) NF-1	NFI (A, B, C, X) · SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4)

(1.5) RF-X	RFX (1, 2, 3, 4, 5, 6, ANK)

(1.6) Basic helix-span-helix (bHSH)	AP-2 (α, β, γ, δ, ε)

(2) Zinc finger DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ)) subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) · MTA (1, 2, 3) · TRPS1

(2.3) Cys₂His₂	General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S1, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (11, 16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE · DIDO1 · GRLF1 · ING (1, 2, 4) · JARID (1A, 1B, 1C, 1D, 2) · JMJD1B

(2.6) WRKY	WRKY

(3) Helix-turn-helix domains

(3.1) Homeodomain	ARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2) · DLX (3, 4, 5) · EMX (1, 2) · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C12, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B) · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · SIX (1, 2, 3, 4, 5) · VAX1 · ZEB (1, 2)

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9) · PRRX (1, 2) · RAX

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) · FOX proteins (A1, A2, A3, C1, C2, D3, D4, E1, E3, F1, G1, H1, I1, J1, J2, K1, K2, L2, M1, N1, N3, O1, O3, O4, P1, P2, P3, P4)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (2, 4, 5) · EGF · ELK (1, 3, 4) · ERF · ETS (1, 2, ERG, SPIB) · ETV (1, 4, 5, 6) · FLI1 · Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2

(3.6) TEA domain	transcriptional enhancer factor (1, 2, 3, 4)

(4) β-Scaffold factors with minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) · NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53 · TBX (1, 2, 3, 5, 19, 21, 22, TBR1, TBR2, TFT) · MYRF · TP63

(4.4) MADS box	Mef2 (A, B, C, D) · SRF

(4.6) TATA binding proteins	TBP · TBPL1

(4.7) High-mobility group	BBX · HMGB (1, 2, 3, 4) · HMGN (1, 2, 3, 4) · HNF (1A, 1B) · LEF1 · SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF (3, 4) · TOX (1, 2, 3, 4)

(4.9) Grainyhead	TFCP2

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) · HBP1

(0.3) Pocket domain	Rb · RBL1 · RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 · EREBP · B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI (16, 35) · MLL (2, 3, T1) · MNDA · NFY (A, B, C) · Rho/Sigma

see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

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SOX11

See also

References

Further reading