SNX2
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| Sorting nexin 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SNX2; TRG-9 | ||||||||||||
| External IDs | OMIM: 605929 MGI: 1915054 HomoloGene: 2332 GeneCards: SNX2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6643 | 67804 | |||||||||||
| Ensembl | ENSG00000205302 | ENSMUSG00000034484 | |||||||||||
| UniProt | O60749 | Q9CWK8 | |||||||||||
| RefSeq (mRNA) | NM_003100 | NM_026386 | |||||||||||
| RefSeq (protein) | NP_003091 | NP_080662 | |||||||||||
| Location (UCSC) | Chr 5: 122.11 – 122.17 Mb | Chr 18: 53.18 – 53.22 Mb | |||||||||||
| PubMed search | |||||||||||||
Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.[1][2]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.[2]
Interactions
SNX2 has been shown to interact with FNBP1.[3][4]
References
- ↑ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol 18 (12): 7278–87. PMC 109309. PMID 9819414.
- ↑ 2.0 2.1 "Entrez Gene: SNX2 sorting nexin 2".
- ↑ Fuchs, U; Rehkamp G F, Slany R, Follo M, Borkhardt A (November 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Lett. (Netherlands) 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. ISSN 0014-5793. PMID 14596906.
- ↑ Fuchs, U; Rehkamp G, Haas O A, Slany R, Kōnig M, Bojesen S, Bohle R M, Damm-Welk C, Ludwig W D, Harbott J, Borkhardt A (July 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (15): 8756–61. doi:10.1073/pnas.121433898. ISSN 0027-8424. PMC 37508. PMID 11438682.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Haft CR, de la Luz Sierra M, Bafford R, et al. (2001). "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes". Mol. Biol. Cell 11 (12): 4105–16. PMC 15060. PMID 11102511.
- Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
- Fuchs U, Rehkamp G, Haas OA, et al. (2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proc. Natl. Acad. Sci. U.S.A. 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508. PMID 11438682.
- Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Fuchs U, Rehkamp GF, Slany R, et al. (2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Lett. 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID 14596906.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gullapalli A, Garrett TA, Paing MM, et al. (2005). "A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking". Mol. Biol. Cell 15 (5): 2143–55. doi:10.1091/mbc.E03-09-0711. PMC 404011. PMID 14978220.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Schaaf CP, Benzing J, Schmitt T, et al. (2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB J. 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961.
- Abdul-Ghani M, Hartman KL, Ngsee JK (2005). "Abstrakt interacts with and regulates the expression of sorting nexin-2". J. Cell. Physiol. 204 (1): 210–8. doi:10.1002/jcp.20285. PMC 2963638. PMID 15690390.
- Carlton JG, Bujny MV, Peter BJ, et al. (2006). "Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport". J. Cell. Sci. 118 (Pt 19): 4527–39. doi:10.1242/jcs.02568. PMC 1904489. PMID 16179610.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Rojas R, Kametaka S, Haft CR, Bonifacino JS (2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors". Mol. Cell. Biol. 27 (3): 1112–24. doi:10.1128/MCB.00156-06. PMC 1800681. PMID 17101778.
- Skånland SS, Wälchli S, Utskarpen A, et al. (2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins". Traffic 8 (3): 297–309. doi:10.1111/j.1600-0854.2006.00527.x. PMID 17319803.
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