SNF1LK2
From Wikipedia, the free encyclopedia
| Salt-inducible kinase 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SIK2; LOH11CR1I; QIK; SNF1LK2 | ||||||||||||
| External IDs | OMIM: 608973 MGI: 2445031 HomoloGene: 22875 ChEMBL: 5699 GeneCards: SIK2 Gene | ||||||||||||
| EC number | 2.7.11.1 | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23235 | 235344 | |||||||||||
| Ensembl | ENSG00000170145 | ENSMUSG00000037112 | |||||||||||
| UniProt | Q9H0K1 | Q8CFH6 | |||||||||||
| RefSeq (mRNA) | NM_015191 | NM_178710 | |||||||||||
| RefSeq (protein) | NP_056006 | NP_848825 | |||||||||||
| Location (UCSC) | Chr 11: 111.47 – 111.6 Mb | Chr 9: 50.89 – 51.01 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.[1][2]
Interactions
SNF1LK2 has been shown to interact with CRTC2.[3]
References
- ↑ Katoh M, Katoh M (April 2004). "Identification and characterization of human FOXN5 and rat Foxn5 genes in silico". Int J Oncol 24 (5): 1339–44. PMID 15067358.
- ↑ "Entrez Gene: SNF1LK2 SNF1-like kinase 2".
- ↑ Screaton, Robert A; Conkright Michael D, Katoh Yoshiko, Best Jennifer L, Canettieri Gianluca, Jeffries Shawn, Guzman Ernesto, Niessen Sherry, Yates John R, Takemori Hiroshi, Okamoto Mitsuhiro, Montminy Marc (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell (United States) 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. ISSN 0092-8674. PMID 15454081.
Further reading
- Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Horike N, Takemori H, Katoh Y, et al. (2003). "Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.". J. Biol. Chem. 278 (20): 18440–7. doi:10.1074/jbc.M211770200. PMID 12624099.
- Katoh M, Katoh M (2004). "Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats.". Int. J. Oncol. 23 (5): 1471–6. PMID 14532992.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
- Screaton RA, Conkright MD, Katoh Y, et al. (2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.". Cell 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Katoh Y, Takemori H, Min L, et al. (2004). "Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm.". Eur. J. Biochem. 271 (21): 4307–19. doi:10.1111/j.1432-1033.2004.04372.x. PMID 15511237.
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