SLC7A5

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Solute carrier family 7 (amino acid transporter light chain, L system), member 5
Identifiers
SymbolsSLC7A5; 4F2LC; CD98; D16S469E; E16; LAT1; MPE16; hLAT1
External IDsOMIM: 600182 MGI: 1298205 HomoloGene: 55759 ChEMBL: 4459 GeneCards: SLC7A5 Gene
Orthologs
SpeciesHumanMouse
Entrez814020539
EnsemblENSG00000103257ENSMUSG00000040010
UniProtQ01650Q9Z127
RefSeq (mRNA)NM_003486NM_011404
RefSeq (protein)NP_003477NP_035534
Location (UCSC)Chr 16:
87.86 – 87.9 Mb		Chr 8:
121.88 – 121.91 Mb
PubMed search
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Solute carrier family 7 member 5 also known as large neutral amino acids transporter small subunit 1 is a protein that in humans is encoded by the SLC7A5 gene.[1]

See also

  • Heterodimeric amino acid transporter

References

  1. ↑ "Entrez Gene: solute carrier family 7 (cationic amino acid transporter". 

Further reading

  • Kaira K, Oriuchi N, Imai H, et al. (2009). "Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma.". Lung Cancer 66 (1): 120–6. doi:10.1016/j.lungcan.2008.12.015. PMID 19171406. 
  • Verrey F, Jack DL, Paulsen IT, et al. (1999). "New glycoprotein-associated amino acid transporters.". J. Membr. Biol. 172 (3): 181–92. doi:10.1007/s002329900595. PMID 10568788. 
  • Nawashiro H, Otani N, Shinomiya N, et al. (2006). "L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors.". Int. J. Cancer 119 (3): 484–92. doi:10.1002/ijc.21866. PMID 16496379. 
  • Nawashiro H, Otani N, Uozumi Y, et al. (2005). "High expression of L-type amino acid transporter 1 in infiltrating glioma cells.". Brain Tumor Pathol 22 (2): 89–91. doi:10.1007/s10014-005-0188-z. PMID 18095110. 
  • Ohno Y, Suda K, Masuko K, et al. (2008). "Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1.". Cancer Sci. 99 (5): 1000–7. doi:10.1111/j.1349-7006.2008.00770.x. PMID 18294274. 
  • Vumma R, Wiesel FA, Flyckt L, et al. (2008). "Functional characterization of tyrosine transport in fibroblast cells from healthy controls.". Neurosci. Lett. 434 (1): 56–60. doi:10.1016/j.neulet.2008.01.028. PMID 18262359. 
  • Endou H, Kanai Y (1999). "[Amino acid transporter molecule as a drug target]". Nippon Yakurigaku Zasshi. 114 Suppl 1: 11P–16P. PMID 10629848. 
  • Nakanishi K, Ogata S, Matsuo H, et al. (2007). "Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract.". Virchows Arch. 451 (3): 681–90. doi:10.1007/s00428-007-0457-9. PMID 17622555. 
  • Kaira K, Oriuchi N, Imai H, et al. (2009). "L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas.". J Surg Oncol 99 (7): 433–8. doi:10.1002/jso.21277. PMID 19347882. 
  • Anderson BM, Schnetz-Boutaud NC, Bartlett J, et al. (2009). "Examination of association of genes in the serotonin system to autism.". Neurogenetics 10 (3): 209–16. doi:10.1007/s10048-009-0171-7. PMID 19184136. 
  • Ring BZ, Seitz RS, Beck RA, et al. (2009). "A novel five-antibody immunohistochemical test for subclassification of lung carcinoma.". Mod. Pathol. 22 (8): 1032–43. doi:10.1038/modpathol.2009.60. PMID 19430419. 
  • Kaira K, Oriuchi N, Imai H, et al. (2008). "Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung.". Pathol. Res. Pract. 204 (8): 553–61. doi:10.1016/j.prp.2008.02.003. PMID 18440724. 
  • Kobayashi K, Ohnishi A, Promsuk J, et al. (2008). "Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells.". Neurosurgery 62 (2): 493–503; discussion 503–4. doi:10.1227/01.neu.0000316018.51292.19. PMID 18382329. 
  • Kühne A, Kaiser R, Schirmer M, et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan.". Pharmacogenet. Genomics 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID 17558306. 
  • Kaira K, Oriuchi N, Imai H, et al. (2008). "Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer.". Br. J. Cancer 98 (4): 742–8. doi:10.1038/sj.bjc.6604235. PMID 18253116. 
  • Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia.". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088. 
  • Kaira K, Oriuchi N, Imai H, et al. (2008). "l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms.". Cancer Sci. 99 (12): 2380–6. doi:10.1111/j.1349-7006.2008.00969.x. PMID 19018776. 
  • Imai H, Kaira K, Oriuchi N, et al. (2009). "L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer.". Histopathology 54 (7): 804–13. doi:10.1111/j.1365-2559.2009.03300.x. PMID 19635099. 
  • Shennan DB, Thomson J (2008). "Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells.". Oncol. Rep. 20 (4): 885–9. PMID 18813831. 
  • Sakata T, Ferdous G, Tsuruta T, et al. (2009). "L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer.". Pathol. Int. 59 (1): 7–18. doi:10.1111/j.1440-1827.2008.02319.x. PMID 19121087. 


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