SLC6A14

From Wikipedia, the free encyclopedia

Solute carrier family 6 (amino acid transporter), member 14

Identifiers

SLC6A14; BMIQ11

External IDs

OMIM: 300444 MGI: 1890216 HomoloGene: 38290 GeneCards: SLC6A14 Gene

Gene Ontology
Molecular function	• neurotransmitter:sodium symporter activity • amino acid transmembrane transporter activity
Cellular component	• plasma membrane • integral to membrane • brush border membrane
Biological process	• amino acid transmembrane transport • cellular amino acid metabolic process • transport • ion transport • amino acid transport • response to toxic substance • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000087916

ENSMUSG00000031089

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr HG1463_PATCH:
115.55 – 115.58 Mb

Chr X:
21.71 – 21.74 Mb

PubMed search

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) is a protein that in humans is encoded by the SLC6A14 gene.^[1]^[2]

SLC6A14 is a member of the Na(+)- and Cl(-)-dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na(+)- and Cl(-)-dependent manner.[supplied by OMIM]^[2]

References

↑ Sloan JL, Mager S (Sep 1999). "Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+)". J Biol Chem 274 (34): 23740–5. doi:10.1074/jbc.274.34.23740. PMID 10446133.
↑ 2.0 2.1 "Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14".

Further reading

Ohman M, Oksanen L, Kaprio J et al. (2000). "Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24". J. Clin. Endocrinol. Metab. 85 (9): 3183–90. doi:10.1210/jc.85.9.3183. PMID 10999806.
Sloan JL, Grubb BR, Mager S (2003). "Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L39–49. doi:10.1152/ajplung.00164.2002 (inactive 2008-10-03). PMID 12388375.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suviolahti E, Oksanen LJ, Ohman M et al. (2004). "The SLC6A14 gene shows evidence of association with obesity". J. Clin. Invest. 112 (11): 1762–72. doi:10.1172/JCI200317491. PMC 281637. PMID 14660752.
Durand E, Boutin P, Meyre D et al. (2004). "Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians". Diabetes 53 (9): 2483–6. doi:10.2337/diabetes.53.9.2483. PMID 15331564.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Gupta N, Miyauchi S, Martindale RG et al. (2005). "Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans". Biochim. Biophys. Acta 1741 (1–2): 215–23. doi:10.1016/j.bbadis.2005.04.002. PMID 15905073.

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