SLC25A10
From Wikipedia, the free encyclopedia
Mitochondrial dicarboxylate carrier is a protein that in humans is encoded by the SLC25A10 gene.[1][2][3]
The dicarboxylate carrier catalyzes the transport of dicarboxylates such as malate and succinate across the mitochondrial membrane in exchange for phosphate, sulfate, and thiosulfate, thus supplying substrates for the Krebs cycle, gluconeogenesis, urea synthesis, and sulfur metabolism.[supplied by OMIM][3]
See also
References
- ↑ Fiermonte G, Palmieri L, Dolce V, Lasorsa FM, Palmieri F, Runswick MJ, Walker JE (Oct 1998). "The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans". J Biol Chem 273 (38): 24754–9. doi:10.1074/jbc.273.38.24754. PMID 9733776.
- ↑ Pannone E, Fiermonte G, Dolce V, Rocchi M, Palmieri F (Mar 1999). "Assignment of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3". Cytogenet Cell Genet 83 (3–4): 238–9. doi:10.1159/000015190. PMID 10072589.
- ↑ 3.0 3.1 "Entrez Gene: SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10".
Further reading
- Fiermonte G, Dolce V, Arrigoni R et al. (2000). "Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family". Biochem. J. 344 Pt 3 (Pt 3): 953–60. PMC 1220721. PMID 10585886.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Douglas MW, Diefenbach RJ, Homa FL et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mizuarai S, Miki S, Araki H et al. (2005). "Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis". J. Biol. Chem. 280 (37): 32434–41. doi:10.1074/jbc.M503152200. PMID 16027120.
- Khanna H, Hurd TW, Lillo C et al. (2005). "RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins". J. Biol. Chem. 280 (39): 33580–7. doi:10.1074/jbc.M505827200. PMC 1249479. PMID 16043481.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Otsuki T, Ota T, Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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