SLC22A18
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| Solute carrier family 22, member 18 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SLC22A18; BWR1A; BWSCR1A; HET; IMPT1; ITM; ORCTL2; SLC22A1L; TSSC5; p45-BWR1A | ||||||||||||
| External IDs | OMIM: 602631 MGI: 1336884 HomoloGene: 1918 GeneCards: SLC22A18 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5002 | 18400 | |||||||||||
| Ensembl | ENSG00000110628 | ENSMUSG00000000154 | |||||||||||
| UniProt | Q96BI1 | Q78KK3 | |||||||||||
| RefSeq (mRNA) | NM_002555 | NM_001042760 | |||||||||||
| RefSeq (protein) | NP_002546 | NP_001036225 | |||||||||||
| Location (UCSC) | Chr 11: 2.92 – 2.95 Mb | Chr 7: 143.47 – 143.5 Mb | |||||||||||
| PubMed search | |||||||||||||
Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene.[1][2][3]
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.[3]
See also
References
- ↑ Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B (May 1998). "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes". Hum Mol Genet 7 (4): 597–608. doi:10.1093/hmg/7.4.597. PMID 9499412.
- ↑ Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M (May 1998). "Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples". Proc Natl Acad Sci U S A 95 (7): 3873–8. doi:10.1073/pnas.95.7.3873. PMC 19930. PMID 9520460.
- ↑ 3.0 3.1 "Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18".
Further reading
- Akiyama S (2002). "[Mechanisms of drug resistance and reversal of the resistance]". Hum. Cell 14 (4): 257–60. PMID 11925925.
- Cooper PR; Smilinich NJ; Day CD et al. (1998). "Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain". Genomics 49 (1): 38–51. doi:10.1006/geno.1998.5221. PMID 9570947.
- Reece M; Prawitt D; Landers J et al. (1998). "Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules". FEBS Lett. 433 (3): 245–50. doi:10.1016/S0014-5793(98)00907-7. PMID 9744804.
- Lee MP; Reeves C; Schmitt A et al. (1998). "Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5". Cancer Res. 58 (18): 4155–9. PMID 9751628.
- Morisaki H, Hatada I, Morisaki T, Mukai T (1999). "A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice". DNA Res. 5 (4): 235–40. doi:10.1093/dnares/5.4.235. PMID 9802569.
- Onyango P; Miller W; Lehoczky J et al. (2001). "Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain". Genome Res. 10 (11): 1697–710. doi:10.1101/gr.161800. PMID 11076855.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Yamada HY, Gorbsky GJ (2006). "Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105". Oncogene 25 (9): 1330–9. doi:10.1038/sj.onc.1209167. PMC 2713668. PMID 16314844.
- Gallagher E; Mc Goldrick A; Chung WY et al. (2006). "Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer". Genomics 88 (1): 12–7. doi:10.1016/j.ygeno.2006.02.004. PMID 16624517.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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