SLC1A5
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| Solute carrier family 1 (neutral amino acid transporter), member 5 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SLC1A5; AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC | ||||||||||||
| External IDs | OMIM: 109190 MGI: 105305 HomoloGene: 21155 GeneCards: SLC1A5 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6510 | 20514 | |||||||||||
| Ensembl | ENSG00000105281 | ENSMUSG00000001918 | |||||||||||
| UniProt | Q15758 | P51912 | |||||||||||
| RefSeq (mRNA) | NM_001145144 | NM_009201 | |||||||||||
| RefSeq (protein) | NP_001138616 | NP_033227 | |||||||||||
| Location (UCSC) | Chr 19: 47.28 – 47.29 Mb | Chr 7: 16.78 – 16.8 Mb | |||||||||||
| PubMed search | |||||||||||||
Neutral amino acid transporter B(0) is a protein that in humans is encoded by the SLC1A5 gene.[1][2][3]
See also
- Glutamate transporter
- Solute carrier family
References
- ↑ Kekuda R, Prasad PD, Fei YJ, Torres-Zamorano V, Sinha S, Yang-Feng TL, Leibach FH, Ganapathy V (Sep 1996). "Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line". J Biol Chem 271 (31): 18657–18661. doi:10.1074/jbc.271.31.18657. PMID 8702519.
- ↑ Rasko JE, Battini JL, Gottschalk RJ, Mazo I, Miller AD (Apr 1999). "The RD114/simian type D retrovirus receptor is a neutral amino acid transporter". Proc Natl Acad Sci U S A 96 (5): 2129–2134. doi:10.1073/pnas.96.5.2129. PMC 26748. PMID 10051606.
- ↑ "Entrez Gene: SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5".
Further reading
- Tailor CS, Nouri A, Zhao Y et al. (1999). "A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses". J. Virol. 73 (5): 4470–4. PMC 104338. PMID 10196349.
- Tailor CS, Marin M, Nouri A et al. (2001). "Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons". J. Biol. Chem. 276 (29): 27221–27230. doi:10.1074/jbc.M100737200. PMID 11350958.
- Lavillette D, Marin M, Ruggieri A et al. (2002). "The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors". J. Virol. 76 (13): 6442–6452. doi:10.1128/JVI.76.13.6442-6452.2002. PMC 136247. PMID 12050356.
- Kudo Y, Boyd CA (2003). "Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization". Placenta 23 (7): 536–541. doi:10.1053/plac.2002.0839. PMID 12175968.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Potter SJ, Lu A, Wilcken B et al. (2003). "Hartnup disorder: polymorphisms identified in the neutral amino acid transporter SLC1A5". J. Inherit. Metab. Dis. 25 (6): 437–448. doi:10.1023/A:1021286714582. PMID 12555937.
- Marin M, Lavillette D, Kelly SM, Kabat D (2003). "N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions". J. Virol. 77 (5): 2936–2945. doi:10.1128/JVI.77.5.2936-2945.2003. PMC 149750. PMID 12584318.
- Kudo Y, Boyd CA, Sargent IL, Redman CW (2003). "Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia". Biochim. Biophys. Acta 1638 (1): 63–71. PMID 12757936.
- Knerr I, Weigel C, Linnemann K et al. (2003). "Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons". Am. J. Obstet. Gynecol. 189 (2): 583–588. doi:10.1067/S0002-9378(03)00538-6. PMID 14520239.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Palmada M, Speil A, Jeyaraj S et al. (2005). "The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2". Biochem. Biophys. Res. Commun. 331 (1): 272–277. doi:10.1016/j.bbrc.2005.03.159. PMID 15845389.
- Uchiyama T, Matsuda Y, Wada M et al. (2005). "Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells". FEBS Lett. 579 (11): 2499–2506. doi:10.1016/j.febslet.2005.03.065. PMID 15848195.
- Bungard CI, McGivan JD (2006). "Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers". Arch. Biochem. Biophys. 443 (1–2): 53–59. doi:10.1016/j.abb.2005.08.016. PMID 16197915.
- Brauers E, Vester U, Zerres K, Eggermann T (2006). "Search for mutations in SLC1A5 (19q13) in cystinuria patients". J. Inherit. Metab. Dis. 28 (6): 1169–1171. doi:10.1007/s10545-005-0094-x. PMID 16435221.
- Gegelashvili M, Rodriguez-Kern A, Pirozhkova I et al. (2006). "High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes". Neurochem. Int. 48 (6–7): 611–5. doi:10.1016/j.neuint.2005.12.033. PMID 16516348.
- Cheynet V, Oriol G, Mallet F (2006). "Identification of the hASCT2-binding domain of the Env ERVWE1/syncytin-1 fusogenic glycoprotein". Retrovirology 3: 41. doi:10.1186/1742-4690-3-41. PMC 1524976. PMID 16820059.
- Chi A, Valencia JC, Hu ZZ et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–3144. doi:10.1021/pr060363j. PMID 17081065.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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