SLC12A7
From Wikipedia, the free encyclopedia
| Solute carrier family 12 (potassium/chloride transporters), member 7 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SLC12A7; KCC4 | ||||||||||||
| External IDs | OMIM: 604879 MGI: 1342283 HomoloGene: 21312 GeneCards: SLC12A7 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10723 | 20499 | |||||||||||
| Ensembl | ENSG00000113504 | ENSMUSG00000017756 | |||||||||||
| UniProt | Q9Y666 | Q9WVL3 | |||||||||||
| RefSeq (mRNA) | NM_006598 | NM_011390 | |||||||||||
| RefSeq (protein) | NP_006589 | NP_035520 | |||||||||||
| Location (UCSC) | Chr 5: 1.05 – 1.11 Mb | Chr 13: 73.76 – 73.82 Mb | |||||||||||
| PubMed search | |||||||||||||
Solute carrier family 12 member 7 is a protein that in humans is encoded by the SLC12A7 gene.[1][2]
See also
References
- ↑ Mount DB, Mercado A, Song L, Xu J, George AL Jr, Delpire E, Gamba G (Jul 1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". J Biol Chem 274 (23): 16355–62. doi:10.1074/jbc.274.23.16355. PMID 10347194.
- ↑ "Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7".
Further reading
- Mercado A, Song L, Vazquez N et al. (2000). "Functional comparison of the K+-Cl− cotransporters KCC1 and KCC4". J. Biol. Chem. 275 (39): 30326–34. doi:10.1074/jbc.M003112200. PMID 10913127.
- Hattori A, Okumura K, Nagase T et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
- Boettger T, Hübner CA, Maier H et al. (2002). "Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4". Nature 416 (6883): 874–8. doi:10.1038/416874a. PMID 11976689.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bräuer M, Frei E, Claes L et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.
- Karadsheh MF, Byun N, Mount DB, Delpire E (2004). "Localization of the KCC4 potassium-chloride cotransporter in the nervous system". Neuroscience 123 (2): 381–91. doi:10.1016/j.neuroscience.2003.10.004. PMID 14698746.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Shen MR, Lin AC, Hsu YM et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hsu YM, Chou CY, Chen HH et al. (2007). "IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness". J. Cell. Physiol. 210 (3): 626–36. doi:10.1002/jcp.20859. PMID 17133354.
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