SKF-82,958

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SKF-82,958
Systematic (IUPAC) name
3-allyl-6-chloro-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
Clinical data
Legal status ?
Identifiers
CAS number 80751-65-1
ATC code ?
PubChem CID 1225
ChemSpider 1188
ChEMBL CHEMBL317741
Chemical data
Formula C19H20ClNO2 
Mol. mass 329.82 g/mol

SKF-82,958 is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist.[1][2] SKF-82,958 and similar D1-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine.[3][4][5][6][7][8][9][10][11]

References

  1. ↑ Pfeiffer, Francis R.; Wilson, James W.; Weinstock, Joseph; Kuo, George Y.; Chambers, Pamela A.; Holden, Kenneth G.; Hahn, Richard A.; Wardell, Joseph R., Jr.; Alfonso, J. Tobia; et al. (1982). "Dopaminergic activity of substituted 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines". Journal of Medicinal Chemistry 25 (4): 352–358. doi:10.1021/jm00346a005. PMID 7069713. 
  2. ↑ Wang JQ, McGinty JF (May 1997). "The full D1 dopamine receptor agonist SKF-82958 induces neuropeptide mRNA in the normosensitive striatum of rats: regulation of D1/D2 interactions by muscarinic receptors". The Journal of Pharmacology and Experimental Therapeutics 281 (2): 972–82. PMID 9152408. 
  3. ↑ Terry P, Katz JL (1992). "Differential antagonism of the effects of dopamine D1-receptor agonists on feeding behavior in the rat". Psychopharmacology 109 (4): 403–9. doi:10.1007/BF02247715. PMID 1365854. 
  4. ↑ Self DW, Stein L (June 1992). "The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats". Brain Research 582 (2): 349–52. doi:10.1016/0006-8993(92)90155-3. PMID 1356585. 
  5. ↑ Rosenzweig-Lipson S, Hesterberg P, Bergman J (September 1994). "Observational studies of dopamine D1 and D2 agonists in squirrel monkeys". Psychopharmacology 116 (1): 9–18. doi:10.1007/BF02244865. PMID 7862937. 
  6. ↑ Kalivas PW, Duffy P (July 1995). "D1 receptors modulate glutamate transmission in the ventral tegmental area". Journal of Neuroscience 15 (7 Pt 2): 5379–88. PMID 7623160. 
  7. ↑ Weed MR, Woolverton WL (December 1995). "The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys". The Journal of Pharmacology and Experimental Therapeutics 275 (3): 1367–74. PMID 8531104. 
  8. ↑ Weed MR, Paul IA, Dwoskin LP, Moore SE, Woolverton WL (October 1997). "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of Pharmacology and Experimental Therapeutics 283 (1): 29–38. PMID 9336305. 
  9. ↑ Abrahams BS, Rutherford JD, Mallet PE, Beninger RJ (February 1998). "Place conditioning with the dopamine D1-like receptor agonist SKF 82958 but not SKF 81297 or SKF 77434". European Journal of Pharmacology 343 (2-3): 111–8. doi:10.1016/S0014-2999(97)01531-8. PMID 9570457. 
  10. ↑ Tidey JW, Bergman J (June 1998). "Drug discrimination in methamphetamine-trained monkeys: agonist and antagonist effects of dopaminergic drugs". The Journal of Pharmacology and Experimental Therapeutics 285 (3): 1163–74. PMID 9618419. 
  11. ↑ Berridge KC, Aldridge JW (September 2000). "Super-stereotypy I: enhancement of a complex movement sequence by systemic dopamine D1 agonists". Synapse 37 (3): 194–204. doi:10.1002/1098-2396(20000901)37:3<194::AID-SYN3>3.0.CO;2-A. PMID 10881041. 

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Peripheral

M: NUT

cof, enz, met

noco, nuvi, sysi/epon, met

drug (A8/11/12)


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