SIRT5

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Sirtuin 5

PDB rendering based on 2b4y.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2B4Y, 2NYR, 3RIG, 3RIY, 4F4U, 4F56, 4G1C, 4HDA

Identifiers

SIRT5; SIR2L5

External IDs

OMIM: 604483 MGI: 1915596 HomoloGene: 40825 GeneCards: SIRT5 Gene

Gene Ontology
Molecular function	• NAD+ ADP-ribosyltransferase activity • zinc ion binding • protein-malonyllysine demalonylase activity • protein-succinyllysine desuccinylase activity • NAD+ binding
Cellular component	• mitochondrion • mitochondrial intermembrane space • mitochondrial matrix
Biological process	• chromatin silencing • protein ADP-ribosylation • protein deacetylation • peptidyl-lysine demalonylation • peptidyl-lysine desuccinylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000124523

ENSMUSG00000054021

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
13.57 – 13.61 Mb

Chr 13:
43.37 – 43.4 Mb

PubMed search

Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5 gene and in other species by the Sirt5 gene.^[1]

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in two transcript variants.^[1]

References

↑ 1.0 1.1 "Entrez Gene: SIRT5 sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)".

Further reading

Frye RA (1999). "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.". Biochem. Biophys. Res. Commun. 260 (1): 273–9. doi:10.1006/bbrc.1999.0897. PMID 10381378.
Frye RA (2000). "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.". Biochem. Biophys. Res. Commun. 273 (2): 793–8. doi:10.1006/bbrc.2000.3000. PMID 10873683.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Mahlknecht U, Ho AD, Letzel S, Voelter-Mahlknecht S (2006). "Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization.". Cytogenet. Genome Res. 112 (3-4): 208–12. doi:10.1159/000089872. PMID 16484774.
Chowdari KV, Northup A, Pless L, et al. (2007). "DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia.". Genes, Brain and Behavior 6 (3): 229–39. doi:10.1111/j.1601-183X.2006.00251.x. PMID 16827919.

PDB gallery

2b4y: Crystal Structure of Human Sirtuin homolog 5

2nyr: Crystal Structure of Human Sirtuin Homolog 5 in Complex with Suramin

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