SIN3B

From Wikipedia, the free encyclopedia
SIN3 transcription regulator homolog B (yeast)

PDB rendering based on 1e91.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsSIN3B; KIAA0700
External IDsOMIM: 607777 MGI: 107158 HomoloGene: 81810 GeneCards: SIN3B Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2330920467
EnsemblENSG00000127511ENSMUSG00000031622
UniProtO75182Q62141
RefSeq (mRNA)NM_015260NM_001113248
RefSeq (protein)NP_056075NP_001106719
Location (UCSC)Chr 19:
16.94 – 16.99 Mb
Chr 8:
72.72 – 72.76 Mb
PubMed search

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.[1][2]

Interactions

SIN3B has been shown to interact with HDAC1,[3][4] Zinc finger and BTB domain-containing protein 16,[5] SUDS3[6] and IKZF1.[4][7]

See also

References

  1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  2. "Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)". 
  3. Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (August 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes Dev. (UNITED STATES) 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. ISSN 0890-9369. PMC 316920. PMID 10444591. 
  4. 4.0 4.1 Koipally, J; Renold A, Kim J, Georgopoulos K (June 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". EMBO J. (ENGLAND) 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. ISSN 0261-4189. PMC 1171390. PMID 10357820. 
  5. David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene (ENGLAND) 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. ISSN 0950-9232. PMID 9627120. 
  6. Alland, Leila; David Gregory, Shen-Li Hong, Potes Jason, Muhle Rebecca, Lee Hye-Chun, Hou Harry, Chen Ken, DePinho Ronald A (April 2002). "Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex". Mol. Cell. Biol. (United States) 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. ISSN 0270-7306. PMC 133736. PMID 11909966. 
  7. Koipally, Joseph; Georgopoulos Katia (August 2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. (United States) 277 (31): 27697–705. doi:10.1074/jbc.M201694200. ISSN 0021-9258. PMID 12015313. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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